Literature DB >> 7520150

Structural analysis of the human nov proto-oncogene and expression in Wilms tumor.

C Martinerie1, V Huff, I Joubert, M Badzioch, G Saunders, L Strong, B Perbal.   

Abstract

We have cloned and sequenced the nov gene (novH) which is the homolog of the chicken nov proto-oncogene overexpressed in avian nephroblastomas. The novH gene is highly conserved and encodes a putative IGF-binding protein similar to that of chicken. We report that relative to autologous normal kidney expression of novH is elevated in Wilms tumors containing predominantly stromal elements and is inversely correlated in these tumors to the expression of WT1. Our results suggest that the regulation of IGFII expression by WT1 and increase of novH in Wilms tumors might be interrelated and represent a key element in tumor development in human.

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Year:  1994        PMID： 7520150

Source DB:  PubMed          Journal:  Oncogene        ISSN： 0950-9232            Impact factor:   9.867


  20 in total

1.  The CCN family of genes: a brief history.

Authors:  B Perbal
Journal:  Mol Pathol       Date:  2001-04

Review 2.  NOV (nephroblastoma overexpressed) and the CCN family of genes: structural and functional issues.

Authors:  B Perbal
Journal:  Mol Pathol       Date:  2001-04

3.  Differential expression of the ccn3 (nov) proto-oncogene in human prostate cell lines and tissues.

Authors:  M Maillard; B Cadot; R Y Ball; K Sethia; D R Edwards; B Perbal; R Tatoud
Journal:  Mol Pathol       Date:  2001-08

4.  Transcriptional down regulation of the nov proto-oncogene in fibroblasts transformed by p60v-src.

Authors:  G Scholz; C Martinerie; B Perbal; H Hanafusa
Journal:  Mol Cell Biol       Date:  1996-02       Impact factor: 4.272

5.  The expression of ccn3 (nov) RNA and protein in the rat central nervous system is developmentally regulated.

Authors:  B Y Su; W Q Cai; C G Zhang; V Martinez; A Lombet; B Perbal
Journal:  Mol Pathol       Date:  2001-06

6.  Increased efficacy of an interleukin-12-secreting herpes simplex virus in a syngeneic intracranial murine glioma model.

Authors:  Elizabeth K Hellums; James M Markert; Jacqueline N Parker; Bin He; Bernard Perbal; Bernard Roizman; Richard J Whitley; Catherine P Langford; Suman Bharara; G Yancey Gillespie
Journal:  Neuro Oncol       Date:  2005-07       Impact factor: 12.300

7.  Differential expression of novH and CTGF in human glioma cell lines.

Authors:  L W Xin; C Martinerie; W Zumkeller; M Westphal; B Perbal
Journal:  Clin Mol Pathol       Date:  1996-04

Review 8.  Cyr61/CTGF/Nov family proteins in gastric carcinogenesis.

Authors:  Tsu-Yao Cheng; Ming-Shiang Wu; Kuo-Tai Hua; Min-Liang Kuo; Ming-Tsan Lin
Journal:  World J Gastroenterol       Date:  2014-02-21       Impact factor: 5.742

9.  novH: differential expression in developing kidney and Wilm's tumors.

Authors:  G Chevalier; H Yeger; C Martinerie; M Laurent; J Alami; P N Schofield; B Perbal
Journal:  Am J Pathol       Date:  1998-06       Impact factor: 4.307

10.  WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors.

Authors:  D Pennica; T A Swanson; J W Welsh; M A Roy; D A Lawrence; J Lee; J Brush; L A Taneyhill; B Deuel; M Lew; C Watanabe; R L Cohen; M F Melhem; G G Finley; P Quirke; A D Goddard; K J Hillan; A L Gurney; D Botstein; A J Levine
Journal:  Proc Natl Acad Sci U S A       Date:  1998-12-08       Impact factor: 11.205
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