Literature DB >> 7520057

Absence of Epstein-Barr virus RNA in multiple sclerosis as assessed by in situ hybridisation.

D A Hilton1, S Love, A Fletcher, J H Pringle.   

Abstract

Epidemiological and serological evidence has suggested a role for Epstein-Barr virus infection in the aetiology of multiple sclerosis. Epstein-Barr virus-specific RNA was looked for in the brains of 10 patients with multiple sclerosis by in situ hybridisation. A total of 21 plaques was examined. In all of these preservation of RNA was shown by hybridisation of control probes to mitochondrial rRNA but no signal was detected with the Epstein-Barr virus probes. It is unlikely that persistent or latent Epstein-Barr virus infection of the CNS occurs in multiple sclerosis, although present findings do not exclude a role for Epstein-Barr virus in the initiation of this disorder.

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Year:  1994        PMID： 7520057      PMCID： PMC1073085          DOI： 10.1136/jnnp.57.8.975

Source DB:  PubMed          Journal:  J Neurol Neurosurg Psychiatry        ISSN： 0022-3050            Impact factor:   10.154


  7 in total

1.  Viral antibody titers. Comparison in patients with multiple sclerosis and rheumatoid arthritis.

Authors:  P V Shirodaria; M Haire; E Fleming; J D Merrett; S A Hawkins; S D Roberts
Journal:  Arch Neurol       Date:  1987-12

2.  Epstein-Barr viral DNA in Hodgkin's disease: amplification and detection using the polymerase chain reaction.

Authors:  D Brocksmith; C A Angel; J H Pringle; I Lauder
Journal:  J Pathol       Date:  1991-09       Impact factor: 7.996

3.  Structural analyses of EBER1 and EBER2 ribonucleoprotein particles present in Epstein-Barr virus-infected cells.

Authors:  J N Glickman; J G Howe; J A Steitz
Journal:  J Virol       Date:  1988-03       Impact factor: 5.103

4.  Epstein-Barr nuclear antigen and viral capsid antigen antibody titers in multiple sclerosis.

Authors:  P D Larsen; L C Bloomer; P F Bray
Journal:  Neurology       Date:  1985-03       Impact factor: 9.910

5.  Epstein-Barr virus antibodies in multiple sclerosis.

Authors:  C V Sumaya; L W Myers; G W Ellison
Journal:  Arch Neurol       Date:  1980-02

6.  Demonstration of Coxsackie virus RNA in formalin-fixed tissue sections from childhood myocarditis cases by in situ hybridization and the polymerase chain reaction.

Authors:  D A Hilton; S Variend; J H Pringle
Journal:  J Pathol       Date:  1993-05       Impact factor: 7.996

7.  Demyelinating disease after neurologically complicated primary Epstein-Barr virus infection.

Authors:  P F Bray; K W Culp; D E McFarlin; H S Panitch; R D Torkelson; J P Schlight
Journal:  Neurology       Date:  1992-02       Impact factor: 9.910
  7 in total
  15 in total

Review 1.  99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: Epstein-Barr virus and multiple sclerosis: epidemiological evidence.

Authors:  A Ascherio; K L Munger
Journal:  Clin Exp Immunol       Date:  2010-04       Impact factor: 4.330

2.  Multiple sclerosis and Epstein-Barr virus.

Authors:  Ruth Ann Marrie; Christina Wolfson
Journal:  Can J Infect Dis       Date:  2002-03

3.  Identification of Epstein-Barr virus proteins as putative targets of the immune response in multiple sclerosis.

Authors:  Sabine Cepok; Dun Zhou; Rajneesh Srivastava; Stefan Nessler; Susanne Stei; Konrad Büssow; Norbert Sommer; Bernhard Hemmer
Journal:  J Clin Invest       Date:  2005-04-14       Impact factor: 14.808

4.  Absence of Epstein-Barr virus in the brain and CSF of patients with multiple sclerosis.

Authors:  S A Sargsyan; A J Shearer; A M Ritchie; M P Burgoon; S Anderson; B Hemmer; C Stadelmann; S Gattenlöhner; G P Owens; D Gilden; J L Bennett
Journal:  Neurology       Date:  2010-03-10       Impact factor: 9.910

5.  The role of infections in the pathogenesis and course of multiple sclerosis.

Authors:  Siddharama Pawate; Subramaniam Sriram
Journal:  Ann Indian Acad Neurol       Date:  2010-04       Impact factor: 1.383

Review 6.  B cells in multiple sclerosis.

Authors:  Mark P Burgoon; Donald H Gilden; Gregory P Owens
Journal:  Front Biosci       Date:  2004-01-01

7.  Epstein-Barr virus infection is not a characteristic feature of multiple sclerosis brain.

Authors:  Simon N Willis; Christine Stadelmann; Scott J Rodig; Tyler Caron; Stefan Gattenloehner; Scott S Mallozzi; Jill E Roughan; Stefany E Almendinger; Megan M Blewett; Wolfgang Brück; David A Hafler; Kevin C O'Connor
Journal:  Brain       Date:  2009-12       Impact factor: 13.501

Review 8.  Epstein-Barr virus in systemic lupus erythematosus, rheumatoid arthritis and multiple sclerosis—association and causation.

Authors:  Andreas Lossius; Jorunn N Johansen; Øivind Torkildsen; Frode Vartdal; Trygve Holmøy
Journal:  Viruses       Date:  2012-12       Impact factor: 5.048

9.  Dysregulated Epstein-Barr virus infection in the multiple sclerosis brain.

Authors:  Barbara Serafini; Barbara Rosicarelli; Diego Franciotta; Roberta Magliozzi; Richard Reynolds; Paola Cinque; Laura Andreoni; Pankaj Trivedi; Marco Salvetti; Alberto Faggioni; Francesca Aloisi
Journal:  J Exp Med       Date:  2007-11-05       Impact factor: 14.307

10.  Epstein-Barr virus is present in the brain of most cases of multiple sclerosis and may engage more than just B cells.

Authors:  Asma Hassani; John R Corboy; Suhail Al-Salam; Gulfaraz Khan
Journal:  PLoS One       Date:  2018-02-02       Impact factor: 3.240
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