Literature DB >> 7519861

Epitope discovery using peptide libraries displayed on phage.

R Cortese1, F Felici, G Galfre, A Luzzago, P Monaci, A Nicosia.   

Abstract

Peptides displayed on phage, which mimic continuous and discontinuous epitopes, can be selected using purified antibodies or preparations of polyclonal serum. This review describes recent advances in this field, discusses the application of phage-display technology to the diagnosis of human diseases, and presents new ideas for the preparation of vaccines directed against specific epitopes on a pathogen.

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Year:  1994        PMID： 7519861     DOI： 10.1016/0167-7799(94)90137-6

Source DB:  PubMed          Journal:  Trends Biotechnol        ISSN： 0167-7799            Impact factor:   19.536


  27 in total

1.  Identifying diagnostic peptides for lyme disease through epitope discovery.

Authors:  G A Kouzmitcheva; V A Petrenko; G P Smith
Journal:  Clin Diagn Lab Immunol       Date:  2001-01

2.  Processing and functional display of the 86 kDa heterodimeric penicillin G acylase on the surface of phage fd.

Authors:  R M Verhaert; J Van Duin; W J Quax
Journal:  Biochem J       Date:  1999-09-01       Impact factor: 3.857

3.  Epitope mapping of trans-sialidase from Trypanosoma cruzi reveals the presence of several cross-reactive determinants.

Authors:  T A Pitcovsky; J Mucci; P Alvarez; M S Leguizamón; O Burrone; P M Alzari; O Campetella
Journal:  Infect Immun       Date:  2001-03       Impact factor: 3.441

4.  Structure of a malaria parasite antigenic determinant displayed on filamentous bacteriophage determined by NMR spectroscopy: implications for the structure of continuous peptide epitopes of proteins.

Authors:  M Monette; S J Opella; J Greenwood; A E Willis; R N Perham
Journal:  Protein Sci       Date:  2001-06       Impact factor: 6.725

5.  The rational design of a 'type 88' genetically stable peptide display vector in the filamentous bacteriophage fd.

Authors:  D Enshell-Seijffers; L Smelyanski; J M Gershoni
Journal:  Nucleic Acids Res       Date:  2001-05-15       Impact factor: 16.971

6.  Neutralizing human monoclonal antibodies to conformational epitopes of human T-cell lymphotropic virus type 1 and 2 gp46.

Authors:  K G Hadlock; J Rowe; S Perkins; P Bradshaw; G Y Song; C Cheng; J Yang; R Gascon; J Halmos; S M Rehman; M S McGrath; S K Foung
Journal:  J Virol       Date:  1997-08       Impact factor: 5.103

7.  Selecting open reading frames from DNA.

Authors:  Paola Zacchi; Daniele Sblattero; Fiorella Florian; Roberto Marzari; Andrew R M Bradbury
Journal:  Genome Res       Date:  2003-05       Impact factor: 9.043

8.  Exploring antibody recognition of sequence space through random-sequence peptide microarrays.

Authors:  Rebecca F Halperin; Phillip Stafford; Stephen Albert Johnston
Journal:  Mol Cell Proteomics       Date:  2010-11-09       Impact factor: 5.911

9.  Use of Peptide library screening to detect a previously unknown linear diagnostic epitope: proof of principle by use of lyme disease sera.

Authors:  Carl V Hamby; Marta Llibre; Sandeepa Utpat; Gary P Wormser
Journal:  Clin Diagn Lab Immunol       Date:  2005-07

10.  Phage Therapy - Everything Old is New Again.

Authors:  Andrew M Kropinski
Journal:  Can J Infect Dis Med Microbiol       Date:  2006-09       Impact factor: 2.471
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