Literature DB >> 7518534

Differential effects of flanking residues on presentation of epitopes from chimeric peptides.

C C Bergmann1, L Tong, R Cua, J Sensintaffar, S Stohlman.   

Abstract

Chimeric peptides in which the optimal H-2d mouse hepatitis virus nucleocapsid (pN) and human immunodeficiency virus type 1 (p18) epitopes, separated by 38, 7, or 2 amino acids, were expressed from a single open reading frame by using recombinant vaccinia viruses to analyze antigen processing of proximal class I-restricted epitopes. Recognition of the carboxy-terminal Dd-restricted p18 epitope was independent of the amino-terminal flanking residues. By contrast, proximity of the carboxy-terminal epitope decreased recognition of the amino-terminal Ld-restricted pN epitope. Immunization resulted in the induction of both p18- and pN-specific antiviral cytotoxic T lymphocytes, irrespective of the number of amino acids separating the epitopes.

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Year:  1994        PMID： 7518534      PMCID： PMC236480     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  27 in total

1.  Immunodominance: intramolecular competition between T cell epitopes.

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Journal:  J Immunol       Date:  1991-04-01       Impact factor: 5.422

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Journal:  J Virol       Date:  1991-07       Impact factor: 5.103

3.  Efficient processing of an antigenic sequence for presentation by MHC class I molecules depends on its neighboring residues in the protein.

Authors:  M Del Val; H J Schlicht; T Ruppert; M J Reddehase; U H Koszinowski
Journal:  Cell       Date:  1991-09-20       Impact factor: 41.582

Review 4.  Adhesion receptors of the immune system.

Authors:  T A Springer
Journal:  Nature       Date:  1990-08-02       Impact factor: 49.962

5.  Slower processing, weaker beta 2-M association, and lower surface expression of H-2Ld are influenced by its amino terminus.

Authors:  J C Beck; T H Hansen; S E Cullen; D R Lee
Journal:  J Immunol       Date:  1986-08-01       Impact factor: 5.422

Review 6.  MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation.

Authors:  R N Germain
Journal:  Cell       Date:  1994-01-28       Impact factor: 41.582

7.  Cap-independent translation of mRNA conferred by encephalomyocarditis virus 5' sequence improves the performance of the vaccinia virus/bacteriophage T7 hybrid expression system.

Authors:  O Elroy-Stein; T R Fuerst; B Moss
Journal:  Proc Natl Acad Sci U S A       Date:  1989-08       Impact factor: 11.205

8.  Recognition of oligonucleotide-encoded T cell epitopes introduced into a gene unrelated to the original antigen.

Authors:  G Chimini; P Pala; J Sire; B R Jordan; J L Maryanski
Journal:  J Exp Med       Date:  1989-01-01       Impact factor: 14.307

9.  Flanking sequences influence the presentation of an endogenously synthesized peptide to cytotoxic T lymphocytes.

Authors:  L C Eisenlohr; J W Yewdell; J R Bennink
Journal:  J Exp Med       Date:  1992-02-01       Impact factor: 14.307

10.  Presentation of viral antigen to class I major histocompatibility complex-restricted cytotoxic T lymphocyte. Recognition of an immunodominant influenza hemagglutinin site by cytotoxic T lymphocyte is independent of the position of the site in the hemagglutinin translation product.

Authors:  Y S Hahn; V L Braciale; T J Braciale
Journal:  J Exp Med       Date:  1991-09-01       Impact factor: 14.307
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  18 in total

1.  Induction of a protective capsular polysaccharide antibody response to a multiepitope DNA vaccine encoding a peptide mimic of meningococcal serogroup C capsular polysaccharide.

Authors:  Deborah M Prinz; S Louise Smithson; Thomas Kieber-Emmons; M A Julie Westerink
Journal:  Immunology       Date:  2003-10       Impact factor: 7.397

2.  The design and implementation of the immune epitope database and analysis resource.

Authors:  Bjoern Peters; John Sidney; Phil Bourne; Huynh-Hoa Bui; Soeren Buus; Grace Doh; Ward Fleri; Mitch Kronenberg; Ralph Kubo; Ole Lund; David Nemazee; Julia V Ponomarenko; Muthu Sathiamurthy; Stephen P Schoenberger; Scott Stewart; Pamela Surko; Scott Way; Steve Wilson; Alessandro Sette
Journal:  Immunogenetics       Date:  2005-05-14       Impact factor: 2.846

3.  A virus-specific CD8+ T cell immunodominance hierarchy determined by antigen dose and precursor frequencies.

Authors:  Nicole L La Gruta; Katherine Kedzierska; Ken Pang; Richard Webby; Miles Davenport; Weisan Chen; Stephen J Turner; Peter C Doherty
Journal:  Proc Natl Acad Sci U S A       Date:  2006-01-17       Impact factor: 11.205

4.  DNA immunization with minigenes: low frequency of memory cytotoxic T lymphocytes and inefficient antiviral protection are rectified by ubiquitination.

Authors:  F Rodriguez; L L An; S Harkins; J Zhang; M Yokoyama; G Widera; J T Fuller; C Kincaid; I L Campbell; J L Whitton
Journal:  J Virol       Date:  1998-06       Impact factor: 5.103

5.  Efficient processing of the immunodominant, HLA-A*0201-restricted human immunodeficiency virus type 1 cytotoxic T-lymphocyte epitope despite multiple variations in the epitope flanking sequences.

Authors:  C Brander; O O Yang; N G Jones; Y Lee; P Goulder; R P Johnson; A Trocha; D Colbert; C Hay; S Buchbinder; C C Bergmann; H J Zweerink; S Wolinsky; W A Blattner; S A Kalams; B D Walker
Journal:  J Virol       Date:  1999-12       Impact factor: 5.103

6.  An endoplasmic reticulum-targeting signal sequence enhances the immunogenicity of an immunorecessive simian virus 40 large T antigen cytotoxic T-lymphocyte epitope.

Authors:  T M Fu; L M Mylin; T D Schell; I Bacik; G Russ; J W Yewdell; J R Bennink; S S Tevethia
Journal:  J Virol       Date:  1998-02       Impact factor: 5.103

7.  Hierarchy among multiple H-2b-restricted cytotoxic T-lymphocyte epitopes within simian virus 40 T antigen.

Authors:  L M Mylin; R H Bonneau; J D Lippolis; S S Tevethia
Journal:  J Virol       Date:  1995-11       Impact factor: 5.103

8.  Mouse hepatitis virus-specific cytotoxic T lymphocytes protect from lethal infection without eliminating virus from the central nervous system.

Authors:  S A Stohlman; C C Bergmann; R C van der Veen; D R Hinton
Journal:  J Virol       Date:  1995-02       Impact factor: 5.103

9.  Antiviral protective immunity induced by major histocompatibility complex class I molecule-restricted viral T-lymphocyte epitopes inserted in various positions in immunologically self and nonself proteins.

Authors:  G Weidt; W Deppert; S Buchhop; H Dralle; F Lehmann-Grube
Journal:  J Virol       Date:  1995-04       Impact factor: 5.103

10.  Functional analysis of amino acid residues encompassing and surrounding two neighboring H-2Db-restricted cytotoxic T-lymphocyte epitopes in simian virus 40 tumor antigen.

Authors:  J D Lippolis; L M Mylin; D T Simmons; S S Tevethia
Journal:  J Virol       Date:  1995-05       Impact factor: 5.103
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