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Literature DB >> 7517825

Acute effects of tramadol in methadone-maintained volunteers.

Abstract

The opioid agonist and antagonist properties of tramadol were assessed in 6 male opioid-dependent volunteers enrolled in a methadone maintenance programme. Subjects participated in 3 experimental sessions in which the effects of intramuscular tramadol 100 and 300 mg and placebo were evaluated. Tramadol neither produced morphine-like effects nor precipitated a withdrawal syndrome; its subjective, behavioural and physiological effects were not different from those of placebo. Although the results of this study suggest that tramadol has a low abuse liability in opioid-dependent subjects, higher doses should be tested to confirm these data.

Entities: Chemical Disease

Mesh：

Substances：
Tramadol
Methadone

Year: 1994 PMID： 7517825 DOI： 10.2165/00003495-199400471-00007

Source DB: PubMed Journal: Drugs ISSN： 0012-6667 Impact factor: 9.546

11 in total

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15 in total

1. Effects of repeated tramadol and morphine administration on psychomotor and cognitive performance in opioid-dependent volunteers.

Authors: Miriam Z Mintzer; Ryan K Lanier; Michelle R Lofwall; George E Bigelow; Eric C Strain
Journal: Drug Alcohol Depend Date: 2010-06-09 Impact factor: 4.492

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Journal: Drugs Date: 1994 Impact factor: 9.546

3. All-Cause Mortality Associated with Tramadol Use: A Case-Crossover Study.

Authors: Sohyun Jeong; Ha Jin Tchoe; Junqing Li; Ju-Young Shin
Journal: Drug Saf Date: 2019-06 Impact factor: 5.606

4. The effects of tramadol on static and dynamic pupillometry in healthy subjects--the relationship between pharmacodynamics, pharmacokinetics and CYP2D6 metaboliser status.

Authors: Frank Fliegert; Burkhard Kurth; Karin Göhler
Journal: Eur J Clin Pharmacol Date: 2005-05-20 Impact factor: 2.953

5. Physical dependence potential of daily tramadol dosing in humans.

Authors: Ryan K Lanier; Michelle R Lofwall; Miriam Z Mintzer; George E Bigelow; Eric C Strain
Journal: Psychopharmacology (Berl) Date: 2010-06-30 Impact factor: 4.530

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Authors: Stefan Grond; Armin Sablotzki
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Authors: David H Epstein; Kenzie L Preston; Donald R Jasinski
Journal: Biol Psychol Date: 2006-02-23 Impact factor: 3.251