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Literature DB >> 7517489

Quantitation of angiogenesis and antiangiogenesis in the chick embryo chorioallantoic membrane.

Abstract

A novel method for quantitating angiogenesis and its inhibition has been developed for the chick embryo. The method is based on the vertical growth of new capillary blood vessels into a collagen gel through two parallel nylon meshes which align the capillaries for counting. Angiogenesis is induced by basic fibroblast growth factor contained within the gel and slowly released by aluminum sucrose octasulfate (sucralfate) or by tumor cells implanted on the gel. The potency of four different angiogenesis inhibitors was compared at concentrations of 0.6 to 600 nmole. This technique may facilitate the discovery and development of angiogenesis inhibitors for clinical application.

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Year: 1994 PMID： 7517489 DOI： 10.1006/mvre.1994.1003

Source DB: PubMed Journal: Microvasc Res ISSN： 0026-2862 Impact factor: 3.514

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Cited

43 in total

1. The antiangiogenic activity of cleaved high molecular weight kininogen is mediated through binding to endothelial cell tropomyosin.

Authors: Jing-Chuan Zhang; Fernando Donate; Xiaoping Qi; Nicholas P Ziats; Jose C Juarez; Andrew P Mazar; Yuan-Ping Pang; Keith R McCrae
Journal: Proc Natl Acad Sci U S A Date: 2002-08-26 Impact factor: 11.205

Review 2. Current methods for assaying angiogenesis in vitro and in vivo.

Authors: Carolyn A Staton; Stephen M Stribbling; Simon Tazzyman; Russell Hughes; Nicola J Brown; Claire E Lewis
Journal: Int J Exp Pathol Date: 2004-10 Impact factor: 1.925

3. Improved growth factor directed vascularization into fibrin constructs through inclusion of additional extracellular molecules.

Authors: J D Smith; M E Melhem; K T Magge; A S Waggoner; P G Campbell
Journal: Microvasc Res Date: 2007-01-16 Impact factor: 3.514

10. Differential effects of angiostatic steroids and dexamethasone on angiogenesis and cytokine levels in rat sponge implants.

Authors: Y Hori; D E Hu; K Yasui; R L Smither; G A Gresham; T P Fan
Journal: Br J Pharmacol Date: 1996-08 Impact factor: 8.739

Quantitation of angiogenesis and antiangiogenesis in the chick embryo chorioallantoic membrane.

1. The antiangiogenic activity of cleaved high molecular weight kininogen is mediated through binding to endothelial cell tropomyosin.

Review 2. Current methods for assaying angiogenesis in vitro and in vivo.

3. Improved growth factor directed vascularization into fibrin constructs through inclusion of additional extracellular molecules.

4. Tumor endothelial cell tube formation model for determining anti-angiogenic activity of a tRNA synthetase cytokine.

5. Evaluation of metastatic and angiogenic potentials of human colon carcinoma cells in chick embryo model systems.

6. Pharmacoproteomic analysis of a novel cell-permeable peptide inhibitor of tumor-induced angiogenesis.

Review 7. The preclinical evaluation of angiogenesis inhibitors.

8. Vascular endothelial growth factor C induces angiogenesis in vivo.

9. Expression of soluble, biologically active recombinant human tumstatin in Escherichia coli.

10. Differential effects of angiostatic steroids and dexamethasone on angiogenesis and cytokine levels in rat sponge implants.