Literature DB >> 7515959

Nature of the reactive epitopes in Paracoccidioides brasiliensis polysaccharide antigen.

E G Rodrigues1, L R Travassos.   

Abstract

Fava Nettos' polysaccharide antigen (FNPA), shown to detect humoral and cellular responses in paracoccidioidomycosis, was investigated. Skin tests with FNPA were negative after alkaline hydrolysis or depletion of gp43 peptide epitopes. Purified antibodies to FNPA or gp43 from paracoccidioidomycosis patients cross-reacted, showing common epitopes and FNPA-specific ones. Normal human sera, in contrast to paracoccidioidomycosis sera, were unreactive with gp43 but recognized epitopes of FNPA susceptible to alkaline hydrolysis and pronase treatment. Histoplasmosis patients sera strongly reacted with FNPA carbohydrate epitopes.

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Year:  1994        PMID： 7515959

Source DB:  PubMed          Journal:  J Med Vet Mycol        ISSN： 0268-1218


  15 in total

1.  Case Report: Misleading Serological Diagnosis of Paracoccidioidomycosis in a Young Patient with the Acute Form Disease: Paracoccidioides brasiliensis or Paracoccidioides lutzii?

Authors:  Renata Buccheri; Vanessa Dos Santos Morais; Camila Mika Kamikawa; Monica Scarpelli Martinelli Vidal; Gabriel Naves; Gilda Maria Barbaro Del Negro; Adriana Pardini Vicentini; Gil Benard
Journal:  Am J Trop Med Hyg       Date:  2018-02-01       Impact factor: 2.345

2.  Expression in bacteria of the gene encoding the gp43 antigen of paracoccidioides brasiliensis: immunological reactivity of the recombinant fusion proteins.

Authors:  Susana N Diniz; Kátia C Carvalho; Patrícia S Cisalpino; José F Silveira; Luiz R Travassos; Rosana Puccia
Journal:  Clin Diagn Lab Immunol       Date:  2002-11

3.  Immunization with P10 peptide increases specific immunity and protects immunosuppressed BALB/c mice infected with virulent yeasts of Paracoccidioides brasiliensis.

Authors:  Julián E Muñoz; Vinicius D Luft; Juliana Amorim; Adriana Magalhães; Luciana Thomaz; Joshua D Nosanchuk; Luiz R Travassos; Carlos P Taborda
Journal:  Mycopathologia       Date:  2014-08-19       Impact factor: 2.574

4.  Mapping of the T-cell epitope in the major 43-kilodalton glycoprotein of Paracoccidioides brasiliensis which induces a Th-1 response protective against fungal infection in BALB/c mice.

Authors:  C P Taborda; M A Juliano; R Puccia; M Franco; L R Travassos
Journal:  Infect Immun       Date:  1998-02       Impact factor: 3.441

5.  Polymorphism in the gene coding for the immunodominant antigen gp43 from the pathogenic fungus Paracoccidioides brasiliensis.

Authors:  F V Morais; T F Barros; M K Fukada; P S Cisalpino; R Puccia
Journal:  J Clin Microbiol       Date:  2000-11       Impact factor: 5.948

6.  The monoclonal antibody against the major diagnostic antigen of Paracoccidioides brasiliensis mediates immune protection in infected BALB/c mice challenged intratracheally with the fungus.

Authors:  R Buissa-Filho; R Puccia; A F Marques; F A Pinto; J E Muñoz; J D Nosanchuk; L R Travassos; C P Taborda
Journal:  Infect Immun       Date:  2008-05-05       Impact factor: 3.441

7.  Characterization of an exocellular serine-thiol proteinase activity in Paracoccidioides brasiliensis.

Authors:  A K Carmona; R Puccia; M C Oliveira; E G Rodrigues; L Juliano; L R Travassos
Journal:  Biochem J       Date:  1995-07-01       Impact factor: 3.857

8.  Evaluation of Paracoccidioides brasiliensis infection by gp 43 intradermal test in rural settlements in Central-West Brazil.

Authors:  Ana Paula da C Marques; Sandra Maria V L Oliveira; Grazielli R Rezende; Dayane A Melo; Sonia M Fernandes-Fitts; Elenir Rose J C Pontes; Maria da Glória Bonecini-Almeida; Zoilo P Camargo; Anamaria M M Paniago
Journal:  Mycopathologia       Date:  2013-04-24       Impact factor: 2.574

Review 9.  Attempts at a peptide vaccine against paracoccidioidomycosis, adjuvant to chemotherapy.

Authors:  Luiz R Travassos; Elaine G Rodrigues; Leo K Iwai; Carlos P Taborda
Journal:  Mycopathologia       Date:  2008 Apr-May       Impact factor: 2.574

10.  Cell-free antigens from Paracoccidioides brasiliensis drive IL-4 production and increase the severity of paracoccidioidomycosis.

Authors:  Karen A Cavassani; Fabrine S M Tristao; Leandro L Oliveira; Fernanda A Rocha; Jaqueline O Vancim; Ana Paula Moreira; Ana Paula Campanelli; Luciano A Panagio; Cristiane M Milanezi; Roberto Martinez; Marcos A Rossi; Joao S Silva
Journal:  PLoS One       Date:  2011-06-22       Impact factor: 3.240
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