Literature DB >> 7515661

t(12;21): a new recurrent translocation in acute lymphoblastic leukemia.

S P Romana1, M Le Coniat, R Berger.   

Abstract

A t(12;21)(p11-p12;q22) was detected by chromosome painting in three patients with acute lymphoblastic leukemia (ALL) among eight ALL cases with 12p- abnormalities. The three leukemias had similar immunophenotypes (DR+, CD10+, CD19+). Fluorescence in situ hybridization (FISH) experiments using YAC clones from 21q21-q22 were performed to better localize the breakpoint on chromosome 21. This breakpoint was localized to 21q22.2 in one patient. Although only one case of ALL with t(12;21) has been reported previously, the present results suggest that t(12;21) is a recurrent translocation in ALL.

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Year:  1994        PMID： 7515661     DOI： 10.1002/gcc.2870090307

Source DB:  PubMed          Journal:  Genes Chromosomes Cancer        ISSN： 1045-2257            Impact factor:   5.006


  17 in total

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Review 2.  Emerging technologies in paediatric leukaemia.

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Journal:  J Clin Invest       Date:  2010-12-22       Impact factor: 14.808

4.  Cytogenetic analysis in childhood acute lymphoblastic leukemia: experience at a single institution in Korea.

Authors:  Young Joo Kwon; Jae Wook Lee; Myung Shin Kim; Pil Sang Jang; Nak Gyun Chung; Dae Chul Jeong; Yong Goo Kim; Kyung Ja Han; Soon Ju Lee; Bin Cho; Hack Ki Kim
Journal:  Int J Hematol       Date:  2008-12-25       Impact factor: 2.490

5.  No chromosome arm unturned: in memory of Roland Berger 1934-2012.

Authors:  C J Harrison; J D Rowley; H Van den Berghe; A Bernheim; M Martineau; M Gautier; M Le Coniat-Busson; S Romana; N Dastugue; A Hagemeijer; P Jonveaux; F Nguyen-Khac; O A Bernard
Journal:  Leukemia       Date:  2014-02       Impact factor: 11.528

6.  Formation of Nup98-containing nuclear bodies in HeLa sublines is linked to genomic rearrangements affecting chromosome 11.

Authors:  Serge Romana; Isabelle Radford-Weiss; Jean-Michel Lapierre; Valérie Doye; Marie-Claude Geoffroy
Journal:  Chromosoma       Date:  2015-12-21       Impact factor: 4.316

7.  Clinical features and prognostic implications of TCF3-PBX1 and ETV6-RUNX1 in adult acute lymphoblastic leukemia.

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8.  Evaluation of ETV6/RUNX1 Fusion and Additional Abnormalities Involving ETV6 and/or RUNX1 Genes Using FISH Technique in Patients with Childhood Acute Lymphoblastic Leukemia.

Authors:  Cigdem Aydin; Zafer Cetin; Ayse Esra Manguoglu; Funda Tayfun; Ozden Altiok Clark; Alphan Kupesiz; Bahar Akkaya; Sibel Berker Karauzum
Journal:  Indian J Hematol Blood Transfus       Date:  2015-06-02       Impact factor: 0.900

9.  Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia.

Authors:  T R Golub; G F Barker; S K Bohlander; S W Hiebert; D C Ward; P Bray-Ward; E Morgan; S C Raimondi; J D Rowley; D G Gilliland
Journal:  Proc Natl Acad Sci U S A       Date:  1995-05-23       Impact factor: 11.205

10.  ETV6-RUNX1 Rearrangement in Tunisian Pediatric B-Lineage Acute Lymphoblastic Leukemia.

Authors:  Abir Gmidène; Hatem Elghezal; Hlima Sennana; Yosra Ben Youssef; Balkiss Meddeb; Moez Elloumi; Abderrahim Khlif; Ali Saad
Journal:  Adv Hematol       Date:  2009-12-22
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