Literature DB >> 7515569

Differential modulation of large-conductance KCa channels by PKA in pregnant and nonpregnant myometrium.

G Pérez1, L Toro.   

Abstract

Uterine excitability depends on ion channel activity, the expression of which is regulated by sexual hormones. We show now that the action of protein kinase A (PKA) on large-conductance calcium-activated K+ (KCa) channel activity also depends on the hormonal status. PKA-dependent phosphorylation of reconstituted KCa channels from midpregnant rats usually stimulated channel activity; in contrast, KCa channels from nonpregnant rat and human myometrium were primarily inhibited by this mechanism. Both effects were reversible by phosphatase treatment. These results suggest that one important factor modulating uterine contractility during pregnancy or the regular cycle may be the differential response of KCa channels toward PKA-induced phosphorylation.

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Year:  1994        PMID： 7515569     DOI： 10.1152/ajpcell.1994.266.5.C1459

Source DB:  PubMed          Journal:  Am J Physiol        ISSN： 0002-9513


  19 in total

Review 1.  A BK (Slo1) channel journey from molecule to physiology.

Authors:  Gustavo F Contreras; Karen Castillo; Nicolás Enrique; Willy Carrasquel-Ursulaez; Juan Pablo Castillo; Verónica Milesi; Alan Neely; Osvaldo Alvarez; Gonzalo Ferreira; Carlos González; Ramón Latorre
Journal:  Channels (Austin)       Date:  2013-09-11       Impact factor: 2.581

Review 2.  Large conductance, Ca2+-activated K+ channels (BKCa) and arteriolar myogenic signaling.

Authors:  Michael A Hill; Yan Yang; Srikanth R Ella; Michael J Davis; Andrew P Braun
Journal:  FEBS Lett       Date:  2010-02-20       Impact factor: 4.124

Review 3.  MaxiK channel partners: physiological impact.

Authors:  Rong Lu; Abderrahmane Alioua; Yogesh Kumar; Mansoureh Eghbali; Enrico Stefani; Ligia Toro
Journal:  J Physiol       Date:  2005-10-20       Impact factor: 5.182

4.  Functional contribution of the endothelial component to the vasorelaxing effect of resveratrol and NS 1619, activators of the large-conductance calcium-activated potassium channels.

Authors:  Vincenzo Calderone; Alma Martelli; Lara Testai; Enrica Martinotti; Maria C Breschi
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2007-01-04       Impact factor: 3.000

Review 5.  Potassium channels and uterine function.

Authors:  Adam M Brainard; Victoria P Korovkina; Sarah K England
Journal:  Semin Cell Dev Biol       Date:  2007-05-24       Impact factor: 7.727

6.  Effects of multiple metal binding sites on calcium and magnesium-dependent activation of BK channels.

Authors:  Lei Hu; Huanghe Yang; Jingyi Shi; Jianmin Cui
Journal:  J Gen Physiol       Date:  2005-12-12       Impact factor: 4.086

7.  The stretch-dependent potassium channel TREK-1 and its function in murine myometrium.

Authors:  Kevin Monaghan; Salah A Baker; Laura Dwyer; William C Hatton; Kyung Sik Park; Kenton M Sanders; Sang Don Koh
Journal:  J Physiol       Date:  2011-01-10       Impact factor: 5.182

Review 8.  Ways and means for left shifts in the MaxiK channel.

Authors:  L Y Jan; Y N Jan
Journal:  Proc Natl Acad Sci U S A       Date:  1997-12-09       Impact factor: 11.205

9.  Alternative splicing determines sensitivity of murine calcium-activated potassium channels to glucocorticoids.

Authors:  L Tian; M S Hammond; H Florance; F A Antoni; M J Shipston
Journal:  J Physiol       Date:  2001-11-15       Impact factor: 5.182

10.  Rapid non-genomic activation of cytosolic cyclic AMP-dependent protein kinase activity and [Ca(2+)](i) by 17beta-oestradiol in female rat distal colon.

Authors:  C M Doolan; S B Condliffe; B J Harvey
Journal:  Br J Pharmacol       Date:  2000-04       Impact factor: 8.739
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