Literature DB >> 7515521

Priming of HIV replication by tRNA(Lys3): role of reverse transcriptase.

S Litvak1, L Sarih-Cottin, M Fournier, M Andreola, L Tarrago-Litvak.   

Abstract

The fundamental role played by reverse transcriptase in the replication of retroviruses has stimulated the study of the mechanism of action of this enzyme. The reverse transcriptase of the type 1 human immunodeficiency virus forms a stable complex with its cognate transfer RNA replication primer (tRNA(Lys3)). Here, we outline the role of this enzyme in the selection of its primer tRNA, the annealing of primer tRNA to the complementary region of the retroviral genome, and the first attempts to use the reverse-transcriptase-tRNA complex as a new target for antiviral agents.

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Year:  1994        PMID： 7515521     DOI： 10.1016/0968-0004(94)90203-8

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  15 in total

1.  Identification of sequences downstream of the primer binding site that are important for efficient replication of human immunodeficiency virus type 1.

Authors:  X Li; C Liang; Y Quan; R Chandok; M Laughrea; M A Parniak; L Kleiman; M A Wainberg
Journal:  J Virol       Date:  1997-08       Impact factor: 5.103

Review 2.  Primer tRNAs for reverse transcription.

Authors:  J Mak; L Kleiman
Journal:  J Virol       Date:  1997-11       Impact factor: 5.103

3.  Efficient encapsidation of human immunodeficiency virus type 1 vectors and further characterization of cis elements required for encapsidation.

Authors:  M S McBride; M D Schwartz; A T Panganiban
Journal:  J Virol       Date:  1997-06       Impact factor: 5.103

4.  The roles of the human immunodeficiency virus type 1 Pol protein and the primer binding site in the placement of primer tRNA(3Lys) onto viral genomic RNA.

Authors:  C Liang; L Rong; N Morin; E Cherry; Y Huang; L Kleiman; M A Wainberg
Journal:  J Virol       Date:  1997-12       Impact factor: 5.103

5.  Human immunodeficiency virus Type 1 nucleocapsid protein (NCp7) directs specific initiation of minus-strand DNA synthesis primed by human tRNA(Lys3) in vitro: studies of viral RNA molecules mutated in regions that flank the primer binding site.

Authors:  X Li; Y Quan; E J Arts; Z Li; B D Preston; H de Rocquigny; B P Roques; J L Darlix; L Kleiman; M A Parniak; M A Wainberg
Journal:  J Virol       Date:  1996-08       Impact factor: 5.103

6.  Molecular requirements for human immunodeficiency virus type 1 plus-strand transfer: analysis in reconstituted and endogenous reverse transcription systems.

Authors:  T Wu; J Guo; J Bess; L E Henderson; J G Levin
Journal:  J Virol       Date:  1999-06       Impact factor: 5.103

7.  Phosphorothioate oligonucleotides derived from human immunodeficiency virus type 1 (HIV-1) primer tRNALys3 are strong inhibitors of HIV-1 reverse transcriptase and arrest viral replication in infected cells.

Authors:  R El Dirani-Diab; L Sarih-Cottin; B Delord; B Dumon; S Moreau; J J Toulme; H Fleury; S Litvak
Journal:  Antimicrob Agents Chemother       Date:  1997-10       Impact factor: 5.191

8.  Human immunodeficiency virus type 1 (HIV-1) viral protein R (Vpr) interacts with Lys-tRNA synthetase: implications for priming of HIV-1 reverse transcription.

Authors:  L A Stark; R T Hay
Journal:  J Virol       Date:  1998-04       Impact factor: 5.103

9.  On the importance of the primer activation signal for initiation of tRNA(lys3)-primed reverse transcription of the HIV-1 RNA genome.

Authors:  Hendrik Huthoff; Katarzyna Bugala; Jan Barciszewski; Ben Berkhout
Journal:  Nucleic Acids Res       Date:  2003-09-01       Impact factor: 16.971

10.  Formation of a functional hepatitis B virus replication initiation complex involves a major structural alteration in the RNA template.

Authors:  J Beck; M Nassal
Journal:  Mol Cell Biol       Date:  1998-11       Impact factor: 4.272
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