| Literature DB >> 7515419 |
F Comby1, J F Lagorce, J Buxeraud, C Raby.
Abstract
Inspection of the chemical structure of ketoconazole indicates that it may have antithyroid activity. The antithyroid action of this drug was demonstrated in-vitro and in-vivo. In-vitro, it was found to form a complex with iodine (formation constant Kc 141 L mol-1), and to inhibit lactoperoxidase (IC50 2 x 10(-4) M). Its effects in-vivo in the rat were assessed by assay of circulating-thyroxine, and from the histological appearance of the thyroid gland. Thyroid gland weight was increased in rats treated with ketoconazole.Entities:
Mesh：
Substances：
Year: 1994 PMID： 7515419 DOI： 10.1111/j.2042-7158.1994.tb03719.x
Source DB: PubMed Journal: J Pharm Pharmacol ISSN： 0022-3573 Impact factor: 3.765