Literature DB >> 7515271

Haemopoietic progenitor cells are reduced in aplastic anaemia.

J Scopes1, M Bagnara, E C Gordon-Smith, S E Ball, F M Gibson.   

Abstract

We investigated the frequencies of early populations of progenitors in aplastic anaemia (AA) bone marrow, from patients with a range of disease severity, compared with normal. Double-colour immunofluorescent staining for CD34 and CD33 was carried out on bone marrow mononuclear cells (BMMC) and analysed using fluorescence activated cell sorting (FACS). AA CD34+ cells were reduced by 68% compared to normal. In addition, AA CD33+ cells and the three progenitor subsets (CD34+/CD33-, CD34+/CD33+ and CD34-/CD33+) were reduced by 44-80%. Our data lend further support for an early stem cell deficiency in AA.

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Year:  1994        PMID： 7515271     DOI： 10.1111/j.1365-2141.1994.tb04761.x

Source DB:  PubMed          Journal:  Br J Haematol        ISSN： 0007-1048            Impact factor:   6.998


  12 in total

1.  Alterations in hematopoietic microenvironment in patients with aplastic anemia.

Authors:  Irina N Shipounova; Tatiana V Petrova; Daria A Svinareva; Kira S Momotuk; Elena A Mikhailova; Nina I Drize
Journal:  Clin Transl Sci       Date:  2009-02       Impact factor: 4.689

2.  Interferon-gamma-induced gene expression in CD34 cells: identification of pathologic cytokine-specific signature profiles.

Authors:  Weihua Zeng; Akira Miyazato; Guibin Chen; Sachiko Kajigaya; Neal S Young; Jaroslaw P Maciejewski
Journal:  Blood       Date:  2005-08-30       Impact factor: 22.113

3.  Efficacy and safety of human adipose tissue-derived mesenchymal stem cells for supporting hematopoiesis.

Authors:  Satoshi Nishiwaki; Takayuki Nakayama; Shigeki Saito; Hiroki Mizuno; Takenori Ozaki; Yoshiyuki Takahashi; Shoichi Maruyama; Tetsuya Nishida; Makoto Murata; Seiji Kojima; Tomoki Naoe
Journal:  Int J Hematol       Date:  2012-07-11       Impact factor: 2.490

4.  The role of RIP1 and RIP3 in the development of aplastic anemia induced by cyclophosphamide and busulphan in mice.

Authors:  Yong-Feng Chen; Zhi-Qiang Zhao; Zhong-Min Wu; Zhen-You Zou; Xin-Jing Luo; Jing Li; Cong Xie; Yong Liang
Journal:  Int J Clin Exp Pathol       Date:  2014-12-01

5.  Alteration in marrow stromal microenvironment and apoptosis mechanisms involved in aplastic anemia: an animal model to study the possible disease pathology.

Authors:  Sumanta Chatterjee; Ranjan Kumar Dutta; Pratima Basak; Prosun Das; Madhurima Das; Jacintha Archana Pereira; Malay Chaklader; Samaresh Chaudhuri; Sujata Law
Journal:  Stem Cells Int       Date:  2010-09-19       Impact factor: 5.443

Review 6.  Pathophysiology and treatment of aplastic anemia.

Authors:  Klaus Geissler
Journal:  Wien Klin Wochenschr       Date:  2003-08-14       Impact factor: 1.704

7.  A new model of busulphan-induced chronic bone marrow aplasia in the female BALB/c mouse.

Authors:  Frances M Gibson; C Michael Andrews; Paraskevi Diamanti; Sian Rizzo; George Macharia; Edward C Gordon-Smith; Thomas Williams; John Turton
Journal:  Int J Exp Pathol       Date:  2003-02       Impact factor: 1.925

8.  Human Acquired Aplastic Anemia Patients' Bone-Marrow-Derived Mesenchymal Stem Cells Are Not Influenced by Hematopoietic Compartment and Maintain Stemness and Immune Properties.

Authors:  Vandana Sharma; Sonali Rawat; Suchi Gupta; Sweta Tamta; Rinkey Sharma; Tulika Seth; Sujata Mohanty
Journal:  Anemia       Date:  2021-04-29

9.  Primitive Sca-1 Positive Bone Marrow HSC in Mouse Model of Aplastic Anemia: A Comparative Study through Flowcytometric Analysis and Scanning Electron Microscopy.

Authors:  Sumanta Chatterjee; Pratima Basak; Prosun Das; Madhurima Das; Jacintha Archana Pereira; Ranjan Kumar Dutta; Malay Chaklader; Samaresh Chaudhuri; Sujata Law
Journal:  Stem Cells Int       Date:  2009-10-28       Impact factor: 5.443

Review 10.  Mesenchymal stem cells in immune-mediated bone marrow failure syndromes.

Authors:  Maria-Christina Kastrinaki; Konstantia Pavlaki; Aristea K Batsali; Elisavet Kouvidi; Irene Mavroudi; Charalampos Pontikoglou; Helen A Papadaki
Journal:  Clin Dev Immunol       Date:  2013-12-10
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