| Literature DB >> 7515011 |
F K Saunders1, J Lawry, D A Winfield, J R Goepel, B W Hancock, R M Sharrard, M H Goyns.
Abstract
2D-gel electrophoresis was used to investigate protein synthesis in leukaemic cells from a series of 15 chronic lymphocytic leukaemia (CLL) patients, and in non-malignant B-cell populations from different sources. The protein synthesis profiles of CD5+ B-cells from umbilical cord blood and from tonsil were determined, and the levels of expression of their proteins were observed to be similar to the CLL cells. The CD5- cells from cord blood resembled peripheral blood B-lymphocytes, and the protein synthesis profile of CD5- cells from tonsils was very complex. One protein was also identified which consistently appeared to be synthesised at a low level in CD5+ B-cells from tonsil but which was always more prominent in CLL cells and other non-malignant B-lymphocytes. On the basis of these data it is possible that the closest non-malignant counterpart to CLL is the CD5+ B-lymphocyte from cord blood.Entities:
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Year: 1994 PMID： 7515011 DOI： 10.1007/bf01920755
Source DB: PubMed Journal: Experientia ISSN： 0014-4754