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Literature DB >> 7514730

DNA damage, oncogenesis and the p53 tumour-suppressor gene.

Abstract

The p53 tumour-suppressor gene encodes a transcription factor which plays a central role in controlling oncogenic development in mouse and humans. Mice which over-express mutant p53 transgenes or have a homozygous deletion of the p53 gene show a high frequency of spontaneous tumour development. This review will focus on recent developments using these transgenic and null mice which suggest that p53 is important in maintaining genomic stability, and is a critical component in the cellular response to ionizing radiation.

Entities: Gene Species

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Year: 1994 PMID： 7514730 DOI： 10.1016/0027-5107(94)90267-4

Source DB: PubMed Journal: Mutat Res ISSN： 0027-5107 Impact factor: 2.433

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Cited

12 in total

10. The association between the T309G polymorphism of the MDM2 gene and sensitivity to anticancer drug is dependent on the p53 mutational status in cellular models.

Authors: N Faur; L Araud; A Laroche-Clary; J Kanno; J Toutain; T Yamori; J Robert; V Le Morvan
Journal: Br J Cancer Date: 2009-06-09 Impact factor: 7.640

DNA damage, oncogenesis and the p53 tumour-suppressor gene.

1. Representativeness of microorgans from human colorectal tumors.

2. Regulation of p53-mediated apoptosis and cell cycle arrest by Steel factor.

Review 3. Molecular aspects of melanocytic dysplastic nevi.

4. Mammalian cells resistant to tumor suppressor genes.

5. Epstein-Barr virus latent membrane protein 1 blocks p53-mediated apoptosis through the induction of the A20 gene.

Review 6. MicroRNAs in inner ear biology and pathogenesis.

7. Decreased DNA repair but normal apoptosis in ultraviolet-irradiated skin of p53-transgenic mice.

Review 8. Apoptosis, cancer and the p53 tumour suppressor gene.

9. Enhancers and suppressors of testicular cancer susceptibility in single- and double-mutant mice.

10. The association between the T309G polymorphism of the MDM2 gene and sensitivity to anticancer drug is dependent on the p53 mutational status in cellular models.