Anxiolytic-like action of centrally administered galanin.

The neuropeptide galanin is present in limbic brain areas important for emotionality. We examined whether central galanin may be involved in mechanisms of anxiety. Rats were tested in a pharmacologically validated animal model of anxiety, the Vogel punished drinking test. A 100% increase of punished responding was seen after 3 nmol galanin i.c.v. After 15 nmol, signs of sedation were seen, and no increase of punished responding could be observed. Drinking motivation, shock thresholds and exploratory locomotor activity were not affected by 3 nmol galanin. These results support a specific anxiolytic-like action of galanin, similar to that of the functionally related peptide, neuropeptide Y.