Literature DB >> 7512243

Neurotrophic effects of substance P on hippocampal neurons in vitro.

C J Whitty1, G Kapatos, M J Bannon.   

Abstract

The potential neurotrophic effect of substance P-like immunoreactivity present in culture media was assessed in rat embryonic day 18 hippocampal cultures. The neurokinin-1 (substance P) receptor antagonist CP-96345 induced neurotoxicity that was dose dependent and attenuated by addition of substance P or the neurokinin-1 agonist [Sar9,Met(O2)11]-SP. These studies suggest that under some conditions neurokinin-1 receptor stimulation promotes neuronal survival.

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Year:  1993        PMID： 7512243     DOI： 10.1016/0304-3940(93)90877-n

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  2 in total

1.  Further evidence for a dissociation between different forms of mnemonic expressions in a mouse model of age-related cognitive decline: effects of tacrine and S 17092, a novel prolyl endopeptidase inhibitor.

Authors:  A Marighetto; K Touzani; N Etchamendy; C C Torrea; G De Nanteuil; D Guez; R Jaffard; P Morain
Journal:  Learn Mem       Date:  2000 May-Jun       Impact factor: 2.460

Review 2.  Rett syndrome and MeCP2: linking epigenetics and neuronal function.

Authors:  Mona D Shahbazian; Huda Y Zoghbi
Journal:  Am J Hum Genet       Date:  2002-11-19       Impact factor: 11.025
  2 in total

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