Literature DB >> 7512160

A domain of murine retrovirus surface protein gp70 mediates cell fusion, as shown in a novel SC-1 cell fusion system.

K B Andersen1.   

Abstract

Virus-induced cell fusion of the fusion-from-without type was observed in SC-1 cells infected with Moloney murine leukemia virus when grown in NIH 3T3 cells. Replication-competent virus mutants with altered surface protein gp70 were examined. Fusion mutations were found in the proline-rich region of gp70. They acted on a step after binding and before or during endocytosis. The fusion mutants had an altered gp70 isomer pattern, presumably caused by different glycosylation. Other mutants with deleted glycans were analyzed, and some which also showed defective fusion were found. The interrelationship of the proline-rich region, glycosylation, and fusion is discussed.

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Year:  1994        PMID： 7512160      PMCID： PMC236808     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  41 in total

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Authors:  D A Zarling; I Keshet
Journal:  Virology       Date:  1979-05       Impact factor: 3.616

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Authors:  J W Hartley; W P Rowe
Journal:  Virology       Date:  1975-05       Impact factor: 3.616

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Authors:  B A Nexo
Journal:  Virology       Date:  1977-04       Impact factor: 3.616

4.  Glycoproteins from murine C-type virus are more acidic in virus derived from transformed cells than from nontransformed cells.

Authors:  J Forchhammer; G Turnock
Journal:  Virology       Date:  1978-07-01       Impact factor: 3.616

5.  Structural proteins of ribonucleic acid tumor viruses. Purification of envelope, core, and internal components.

Authors:  M Strand; J T August
Journal:  J Biol Chem       Date:  1976-01-25       Impact factor: 5.157

6.  Mechanism of murine leukemia virus-induced fusion in rat myoblasts defective in differentiation.

Authors:  P K Wong; P H Yuen; S J Kaufman
Journal:  J Virol       Date:  1977-09       Impact factor: 5.103

7.  Plaque assay techniques for murine leukemia viruses.

Authors:  W P Rowe; W E Pugh; J W Hartley
Journal:  Virology       Date:  1970-12       Impact factor: 3.616

8.  Effect of electric charged molecules on Sindbis virus hemagglutination and hemolysis.

Authors:  P Mastromarino; C Conti; C Petruzziello; R Lapadula; N Orsi
Journal:  Microbiologica       Date:  1992-01

9.  Murine sarcoma and leukemia viruses: assay using clonal lines of contact-inhibited mouse cells.

Authors:  J L Jainchill; S A Aaronson; G J Todaro
Journal:  J Virol       Date:  1969-11       Impact factor: 5.103

10.  Assay for type C virus in mouse sera based on particulate reverse transcriptase activity.

Authors:  P Roy-Burman; M Dougherty; B K Pal; H P Charman; V Klement; M B Gardner
Journal:  J Virol       Date:  1976-09       Impact factor: 5.103
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  24 in total

1.  Role of chimeric murine leukemia virus env beta-turn polyproline spacers in receptor cooperation.

Authors:  S Valsesia-Wittmann
Journal:  J Virol       Date:  2001-09       Impact factor: 5.103

2.  Efficient cell infection by Moloney murine leukemia virus-derived particles requires minimal amounts of envelope glycoprotein.

Authors:  E Bachrach; M Marin; M Pelegrin; G Karavanas; M Piechaczyk
Journal:  J Virol       Date:  2000-09       Impact factor: 5.103

3.  G100R mutation within 4070A murine leukemia virus Env increases virus receptor binding, kinetics of entry, and viral transduction efficiency.

Authors:  Chi-Wei Lu; Lucille O'Reilly; Monica J Roth
Journal:  J Virol       Date:  2003-01       Impact factor: 5.103

4.  Receptor co-operation in retrovirus entry: recruitment of an auxiliary entry mechanism after retargeted binding.

Authors:  S Valsesia-Wittmann; F J Morling; T Hatziioannou; S J Russell; F L Cosset
Journal:  EMBO J       Date:  1997-03-17       Impact factor: 11.598

5.  An envelope glycoprotein of the human endogenous retrovirus HERV-W is expressed in the human placenta and fuses cells expressing the type D mammalian retrovirus receptor.

Authors:  J L Blond; D Lavillette; V Cheynet; O Bouton; G Oriol; S Chapel-Fernandes; B Mandrand; F Mallet; F L Cosset
Journal:  J Virol       Date:  2000-04       Impact factor: 5.103

6.  Efficient transduction by an amphotropic retrovirus vector is dependent on high-level expression of the cell surface virus receptor.

Authors:  P Kurre; H P Kiem; J Morris; S Heyward; J L Battini; A D Miller
Journal:  J Virol       Date:  1999-01       Impact factor: 5.103

7.  Exceptional fusogenicity of Chinese hamster ovary cells with murine retroviruses suggests roles for cellular factor(s) and receptor clusters in the membrane fusion process.

Authors:  D C Siess; S L Kozak; D Kabat
Journal:  J Virol       Date:  1996-06       Impact factor: 5.103

8.  A proline-rich motif downstream of the receptor binding domain modulates conformation and fusogenicity of murine retroviral envelopes.

Authors:  D Lavillette; M Maurice; C Roche; S J Russell; M Sitbon; F L Cosset
Journal:  J Virol       Date:  1998-12       Impact factor: 5.103

9.  The amphotropic and ecotropic murine leukemia virus envelope TM subunits are equivalent mediators of direct membrane fusion: implications for the role of the ecotropic envelope and receptor in syncytium formation and viral entry.

Authors:  J A Ragheb; H Yu; T Hofmann; W F Anderson
Journal:  J Virol       Date:  1995-11       Impact factor: 5.103

10.  Characterization of the proline-rich region of murine leukemia virus envelope protein.

Authors:  B Weimin Wu; P M Cannon; E M Gordon; F L Hall; W F Anderson
Journal:  J Virol       Date:  1998-07       Impact factor: 5.103
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