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Literature DB >> 7511919

Serum copper and zinc levels and copper/zinc ratio in patients with breast cancer.

I Yücel¹, F Arpaci, A Ozet, B Döner, T Karayilanoğlu, A Sayar, O Berk.

Abstract

Serum copper, zinc levels, and the Cu/Zn ratio were evaluated in 31 patients with breast cancer and 35 healthy controls. Copper and zinc were determined by atomic absorbtion spectrophotometry. The mean serum copper level and the mean Cu/Zn ratio in patients with breast cancer were significantly higher than the control group (p < 0.001 and p < 0.001). In addition, the mean serum zinc level in patients with breast cancer was significantly lower than the control group (p < 0.001). Neither serum copper and zinc levels nor the Cu/Zn ratio were of value in discriminating of the disease activity and severity. Interestingly, the Cu/Zn ratio in premenopausal patients was higher than postmenopausal patients (p < 0.05) and this was not related to age. The further combined biological and epidemiological studies are necessary to investigate the roles of copper and zinc in breast cancer.

Entities: Chemical Disease Species

Mesh：

Substances：
Copper
Zinc

Year: 1994 PMID： 7511919 DOI： 10.1007/bf02916818

Source DB: PubMed Journal: Biol Trace Elem Res ISSN： 0163-4984 Impact factor: 3.738

14 in total

1. [Decreased plasma zinc levels in metastatic breast cancer].

Authors: W Holtkamp; J Thiery; H Rauschecker; G A Nagel; H E Reis
Journal: Onkologie Date: 1990-06

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Journal: Cancer Date: 1972-05 Impact factor: 6.860

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Journal: Cancer Date: 1976-01 Impact factor: 6.860

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Journal: Cancer Res Date: 1984-11 Impact factor: 12.701

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Journal: Cancer Date: 1991-02-01 Impact factor: 6.860

9. Hydroxyproline and zinc excretion in patients with neoplastic breast disease.

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10. Value of serum copper levels and erythrocyte sedimentation rates as indicators of disease activity in children with Hodgkin's disease.

Authors: J Wilimas; E Thompson; K L Smith
Journal: Cancer Date: 1978-10 Impact factor: 6.860

11 in total

Review 1. Resveratrol mobilizes endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage: a putative mechanism for chemoprevention of cancer.

Authors: S M Hadi; M F Ullah; A S Azmi; A Ahmad; U Shamim; H Zubair; H Y Khan
Journal: Pharm Res Date: 2010-01-30 Impact factor: 4.200

2. Analysis of serum levels of 15 trace elements in breast cancer patients in Shandong, China.

Authors: Xiao Ding; Meng Jiang; Haiyan Jing; Wei Sheng; Xingwen Wang; Junqing Han; Luhua Wang
Journal: Environ Sci Pollut Res Int Date: 2014-12-19 Impact factor: 4.223

3. Activity-based photoacoustic probe for biopsy-free assessment of copper in murine models of Wilson's disease and liver metastasis.

Authors: Melissa Y Lucero; Yuqi Tang; Chloe J Zhang; Shengzhang Su; Joseph A Forzano; Valeria Garcia; Xin Huang; David Moreno; Jefferson Chan
Journal: Proc Natl Acad Sci U S A Date: 2021-09-07 Impact factor: 11.205

Serum copper and zinc levels and copper/zinc ratio in patients with breast cancer.

1. [Decreased plasma zinc levels in metastatic breast cancer].

2. Value of serum copper measurement in lymphomas and several other malignancies.

3. Copper and zinc concentration in the plasma of leukaemic children.

4. Serum zinc, copper, and the Cu/Zn ratio in patients with benign and malignant breast lesions.

5. Copper and zinc levels in serum from human patients with sarcomas.

6. Comparison between concentrations of trace elements in normal and neoplastic human breast tissue.

7. Plasma copper and zinc levels in patients with malignant tumors of digestive organs: clinical evaluation of the C1/Zn ratio.

8. Zinc and copper in breast cancer. A joint study in northern Italy and southern France.

9. Hydroxyproline and zinc excretion in patients with neoplastic breast disease.

10. Value of serum copper levels and erythrocyte sedimentation rates as indicators of disease activity in children with Hodgkin's disease.

Review 1. Resveratrol mobilizes endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage: a putative mechanism for chemoprevention of cancer.

2. Analysis of serum levels of 15 trace elements in breast cancer patients in Shandong, China.

3. Activity-based photoacoustic probe for biopsy-free assessment of copper in murine models of Wilson's disease and liver metastasis.

4. Zinc Transporter 9 (SLC30A9) Expression Is Decreased in the Vaginal Tissues of Menopausal Women.

5. Serum and hair zinc levels in breast cancer: a meta-analysis.

6. Oxytocin-Monolayer-Based Impedimetric Biosensor for Zinc and Copper Ions.

7. Evaluation of zinc and copper levels in vaginal tissues and whole blood: correlation with age.

8. Comparison of the Index of Nutritional Quality in Breast Cancer Patients With Healthy Women.

9. Changes in Copper, Zinc, and Malondialdehyde Levels and Superoxide Dismutase Activities in Pre-Eclamptic Pregnancies.

10. Serum and tissue zinc in epithelial malignancies: a meta-analysis.