E J Small1, P R Carroll. 1. Department of Medicine, University of California, San Francisco.
Abstract
OBJECTIVE: To evaluate the relationship between antiandrogen withdrawal and change in prostate-specific antigen (PSA) when the antiandrogen in question is other than flutamide. METHODS: Presented is a case of a patient in whom the antiandrogen casodex was discontinued after clinical progression despite combined androgen blockade. RESULTS: A transient decline in serum PSA was observed after casodex withdrawal. CONCLUSIONS: The relationship between antiandrogen withdrawal and a change in PSA may be a general phenomenon, not unique to flutamide.
OBJECTIVE: To evaluate the relationship between antiandrogen withdrawal and change in prostate-specific antigen (PSA) when the antiandrogen in question is other than flutamide. METHODS: Presented is a case of a patient in whom the antiandrogen casodex was discontinued after clinical progression despite combined androgen blockade. RESULTS: A transient decline in serum PSA was observed after casodex withdrawal. CONCLUSIONS: The relationship between antiandrogen withdrawal and a change in PSA may be a general phenomenon, not unique to flutamide.
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