[Perinatal hypoxic CNS lesions in neonates].

The paper reviews the causes of perinatal brain lesions, shows the involvement of disturbances of cellular membrane structural and functional properties and blood-brain barrier permeability in the pathogenesis of hypoxic CNS lesions for neurospecific proteins. It also provides evidence for the principles of management of pregnancy, labor and early neonatality at a risk for cerebral abnormalities to reduce childhood disability.