OBJECTIVE: Our purpose was to demonstrate the clinical efficacy and effect of hormone replacement therapy in menopause on quality of life. STUDY DESIGN: A randomized, open, 6-month comparison of hormone replacement therapy (estradiol transdermal system [Estraderm TTS] plus chlormadinone) and symptomatic treatment (verapipride) was performed. Analysis was by intention to treat. RESULTS: In 499 postmenopausal women with moderate and severe symptoms enrolled by 101 physicians, hormone replacement therapy was superior to symptomatic treatment on all assessments of quality of life and clinical efficacy. The effects were independent of the incidence of hot flushes. CONCLUSION: The effect of hormone replacement therapy on the quality of life of postmenopausal women was significantly superior to symptomatic treatment.
RCT Entities:
OBJECTIVE: Our purpose was to demonstrate the clinical efficacy and effect of hormone replacement therapy in menopause on quality of life. STUDY DESIGN: A randomized, open, 6-month comparison of hormone replacement therapy (estradiol transdermal system [Estraderm TTS] plus chlormadinone) and symptomatic treatment (verapipride) was performed. Analysis was by intention to treat. RESULTS: In 499 postmenopausal women with moderate and severe symptoms enrolled by 101 physicians, hormone replacement therapy was superior to symptomatic treatment on all assessments of quality of life and clinical efficacy. The effects were independent of the incidence of hot flushes. CONCLUSION: The effect of hormone replacement therapy on the quality of life of postmenopausal women was significantly superior to symptomatic treatment.
Authors: Donna Kritz-Silverstein; Denise G Von Muhlen; Theodore G Ganiats; Elizabeth Barrett-Connor Journal: Qual Life Res Date: 2004-02 Impact factor: 4.147
Authors: Rachel Hess; Rebecca C Thurston; Ron D Hays; Chung-Chou H Chang; Stacey N Dillon; Roberta B Ness; Cindy L Bryce; Wishwa N Kapoor; Karen A Matthews Journal: Qual Life Res Date: 2011-07-14 Impact factor: 4.147
Authors: Rogerio A Lobo; Serge Bélisle; William T Creasman; Nancy R Frankel; Neil F Goodman; Janet E Hall; Susan Lee Ivey; Sheryl Kingsberg; Robert Langer; Rebecca Lehman; Donna Behler McArthur; Valerie Montgomery-Rice; Morris Notelovitz; Gary S Packin; Robert W Rebar; MaryEllen Rousseau; Robert S Schenken; Diane L Schneider; Katherine Sherif; Susan Wysocki Journal: MedGenMed Date: 2006