Calcitonin gene-related peptide and substance P immunoreactivity in the monkey trigeminal ganglion, an electron microscopic study.

Calcitonin gene-related peptide (CGRP) and substance P (SP) immunoreactivity was examined in neurons of the monkey trigeminal ganglion. Moreover, CGRP- and SP-positive varicose nerve fibers were found, occasionally forming pericellular arborizations around trigeminal somata, which, at light microscopic level, suggested the existence of synaptic contacts. Electron microscopic investigation however, revealed that although these varicose fibers ran in close range of somata and were containing accumulations of CGRP- and SP-positive vesicles, classical synaptic contacts were not present.