| Literature DB >> 7507684 |
R Fuleihan1, N Ramesh, R S Geha.
Abstract
Ig-isotype switching to IgE requires interleukin-4 and a contact-dependent T-cell signal delivered by the ligand for CD40. The recent discovery that defects in the gene encoding the CD40 ligand are the underlying cause of the X-linked hyper IgM syndrome highlights the role of CD40 and its ligand in Ig-isotype switching.Entities:
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Year: 1993 PMID: 7507684 DOI: 10.1016/0952-7915(93)90113-7
Source DB: PubMed Journal: Curr Opin Immunol ISSN: 0952-7915 Impact factor: 7.486