Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Ethacrynic acid inhibitable Ca2+ and Mg2+-activated membrane adenosine triphosphatase in rat mast cells.

Literature DB >> 75076

Ethacrynic acid inhibitable Ca2+ and Mg2+-activated membrane adenosine triphosphatase in rat mast cells.

Abstract

A crude plasma membrane fraction from the homogenate of purified rat mast cells demonstrates a high degree of Ca2+-dependent and Mg2+-dependent adenosine triphosphatase (ATPase) activity. The microsomal and mitochondrial fractions show negligible amounts of the Ca2+ and Mg2+-activated ATPases. The broad ATPase inhibitor, ethacrynic acid, effectively blocks the mast cell ATPase activity while ouabain demonstrates little inhibitory effect. Correspondingly, ethacrynic acid inhibits histamine release from antigen-challenged mast cells while ouabain does not. Both ATPase inhibition and histamine release inhibition by ethacrynic acid require the presence of the olefinic bond in the ethacrynic acid molecule.

Entities: Chemical Species

Mesh：

Substances：

Year: 1977 PMID： 75076 PMCID： PMC1541169

Source DB: PubMed Journal: Clin Exp Immunol ISSN： 0009-9104 Impact factor: 4.330

27 in total

1. Electron microscopy of freeze-fractured rat peritoneal mast cells.

Authors: E Y Chi; D Lagunoff; J K Koehler
Journal: J Ultrastruct Res Date: 1975-04

2. REAGIN-LIKE ANTIBODIES IN ANIMALS IMMUNE TO HELMINTH PARASITES.

Authors: B M OGILVIE
Journal: Nature Date: 1964-10-03 Impact factor: 49.962

Review 3. ENZYMATIC BASIS FOR ACTIVE TRANSPORT OF NA+ AND K+ ACROSS CELL MEMBRANE.

Authors: J C SKOU
Journal: Physiol Rev Date: 1965-07 Impact factor: 37.312

4. Studies on sodium-potassium-activated adenosinetriphosphatase. IV. Correlation with cation transport sensitive to cardiac glycosides.

Authors: S L BONTING; L L CARAVAGGIO; N M HAWKINS
Journal: Arch Biochem Biophys Date: 1962-09 Impact factor: 4.013

5. Studies on sodium-potassium-activated adenosine triphosphatase. I. Quantitative distribution in several tissues of the cat.

Authors: S L BONTING; K A SIMON; N M HAWKINS
Journal: Arch Biochem Biophys Date: 1961-12 Impact factor: 4.013

6. A method for the fluorometric assay of histamine in tissues.

Authors: P A SHORE; A BURKHALTER; V H COHN
Journal: J Pharmacol Exp Ther Date: 1959-11 Impact factor: 4.030

7. [Cardiac glycosides as inhibitors of active potassium and sodium transport by erythrocyte membrane].

Authors: H J SCHATZMANN
Journal: Helv Physiol Pharmacol Acta Date: 1953

8. Protein measurement with the Folin phenol reagent.

Authors: O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal: J Biol Chem Date: 1951-11 Impact factor: 5.157

9. Phosphatidylserine: selective enhancer of histamine release.

Authors: A Goth; H R Adams; M Knoohuizen
Journal: Science Date: 1971-09-10 Impact factor: 47.728

10. Characterization of calcium-ion-activated adenosine triphosphatase in the plasma membrane of rat mast cells.

Authors: P H Cooper; D R Stanworth
Journal: Biochem J Date: 1976-06-15 Impact factor: 3.857

7 in total

1. Inhibitors of membrane transport reduce lysosomal enzyme secretion from dogfish phagocytes and their killing of sea urchin eggs.

Authors: P Dunham; P Arvan; S Falkow; S Hoffstein; G Weissmann
Journal: Proc Natl Acad Sci U S A Date: 1979-04 Impact factor: 11.205

Ethacrynic acid inhibitable Ca2+ and Mg2+-activated membrane adenosine triphosphatase in rat mast cells.

1. Electron microscopy of freeze-fractured rat peritoneal mast cells.

2. REAGIN-LIKE ANTIBODIES IN ANIMALS IMMUNE TO HELMINTH PARASITES.

Review 3. ENZYMATIC BASIS FOR ACTIVE TRANSPORT OF NA+ AND K+ ACROSS CELL MEMBRANE.

4. Studies on sodium-potassium-activated adenosinetriphosphatase. IV. Correlation with cation transport sensitive to cardiac glycosides.

5. Studies on sodium-potassium-activated adenosine triphosphatase. I. Quantitative distribution in several tissues of the cat.

6. A method for the fluorometric assay of histamine in tissues.

7. [Cardiac glycosides as inhibitors of active potassium and sodium transport by erythrocyte membrane].

8. Protein measurement with the Folin phenol reagent.

9. Phosphatidylserine: selective enhancer of histamine release.

10. Characterization of calcium-ion-activated adenosine triphosphatase in the plasma membrane of rat mast cells.

1. Inhibitors of membrane transport reduce lysosomal enzyme secretion from dogfish phagocytes and their killing of sea urchin eggs.

2. Creatine phosphokinase in rat mast cells.

3. The effect of Na+-K+ ATPase inhibition by ouabain on histamine release from human cutaneous mast cells.

4. Presence of a high-affinity Ca2+- and Mg2+-dependent ATPase in rat peritoneal mast-cell membranes.

5. Evidence for lipoxygenase activity in induction of histamine release from rat peritoneal mast cells by chelated iron.

6. Na+ -K+ pump activity in rat peritoneal mast cells: inhibition by extracellular calcium.

7. Sodium-potassium ATPase inhibition potentiates compound 48/80-induced histamine secretion from mast cells.