Protein restriction (PR) and caloric restriction (CR) compared: effects on DNA damage, carcinogenesis, and oxidative damage.

Protein restriction (PR) and caloric restriction (CR) similarly impinge upon various physiological factors that can significantly inhibit the growth of DNA-damaged tissue and, therefore, carcinogenesis. Whether this effect is largely, or only in part, due to simple inhibition of body weight gain is examined. Among their many other health-improving effects, PR and CR delay the onset of puberty. It has been suggested that animals have developed mechanisms to cope with lean periods and that, when food is limited, resources are diverted from those physiological functions that offer no benefit for immediate survival (e.g., reproductive capacity) to thereby support an increase in the maintenance functions that prolong life. PR has also been shown to affect numerous other varied mechanisms that can affect carcinogenesis, including gene expression and metabolism of xenobiotics. The effects of PR on initiational and promotional growth of DNA-damaged tissue is also discussed. PR also seems to boost antioxidant defenses and inhibit the accumulation of oxidative damage (as does CR). Protein restricted animals have been shown to accumulate more calories, but develop fewer preneoplastic lesions and tumors than their high-protein counterparts. This observation seems quite counter to most ideas about dietary restrictions and CR. Despite the fact that both PR and CR induce many beneficial physiological effects in common, it is possible that PR is the more feasible option for human consideration. The levels of PR likely to improve health without negative side effects are discussed.