Literature DB >> 7507301

Vascular origin of Kaposi's sarcoma. Expression of leukocyte adhesion molecule-1, thrombomodulin, and tissue factor.

Y M Zhang1, S Bachmann, C Hemmer, J van Lunzen, A von Stemm, P Kern, M Dietrich, R Ziegler, R Waldherr, P P Nawroth.   

Abstract

We studied seven cases of Kaposi's sarcomas (KS) obtained from patients with AIDS and one KS from a patient without HIV infection. Antigen expression was studied by immunocytochemistry and mRNA expression by in situ hybridisation. The markers tested were endothelial leukocyte adhesion molecule-1, thrombomodulin, and tissue factor. In all tumors (AIDS and non-AIDS associated) these markers reacted positive, indicating transcription and translation of these genes in KS. The synthesis and expression of tissue factor and thrombomodulin suggests that KS is a tumor that has tissue factor-mediated thrombin formation under the control of thrombomodulin. The expression of thrombomodulin and endothelial leukocyte adhesion molecule-1 provides evidence for the vascular origin of KS.

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Year:  1994        PMID： 7507301      PMCID： PMC1887124     

Source DB:  PubMed          Journal:  Am J Pathol        ISSN： 0002-9440            Impact factor:   4.307


  38 in total

1.  Human tissue factor: cDNA sequence and chromosome localization of the gene.

Authors:  E M Scarpati; D Wen; G J Broze; J P Miletich; R R Flandermeyer; N R Siegel; J E Sadler
Journal:  Biochemistry       Date:  1987-08-25       Impact factor: 3.162

2.  Human thrombomodulin: complete cDNA sequence and chromosome localization of the gene.

Authors:  D Z Wen; W A Dittman; R D Ye; L L Deaven; P W Majerus; J E Sadler
Journal:  Biochemistry       Date:  1987-07-14       Impact factor: 3.162

3.  The regulation of natural anticoagulant pathways.

Authors:  C T Esmon
Journal:  Science       Date:  1987-03-13       Impact factor: 47.728

4.  Interleukin 1 induces endothelial cell procoagulant while suppressing cell-surface anticoagulant activity.

Authors:  P P Nawroth; D A Handley; C T Esmon; D M Stern
Journal:  Proc Natl Acad Sci U S A       Date:  1986-05       Impact factor: 11.205

5.  The expression of endothelial cell surface antigens by AIDS-associated Kaposi's sarcoma. Evidence for a vascular endothelial cell origin.

Authors:  J L Rutgers; R Wieczorek; F Bonetti; K L Kaplan; D N Posnett; A E Friedman-Kien; D M Knowles
Journal:  Am J Pathol       Date:  1986-03       Impact factor: 4.307

6.  Subtle clues to diagnosis by conventional microscopy. The patch stage of Kaposi's sarcoma.

Authors:  A B Ackerman
Journal:  Am J Dermatopathol       Date:  1979       Impact factor: 1.533

7.  QBEnd/10: a new immunostain for the routine diagnosis of Kaposi's sarcoma.

Authors:  E A Sankey; L More; A P Dhillon
Journal:  J Pathol       Date:  1990-07       Impact factor: 7.996

8.  Interleukin 1 acts on cultured human vascular endothelium to increase the adhesion of polymorphonuclear leukocytes, monocytes, and related leukocyte cell lines.

Authors:  M P Bevilacqua; J S Pober; M E Wheeler; R S Cotran; M A Gimbrone
Journal:  J Clin Invest       Date:  1985-11       Impact factor: 14.808

9.  Thrombomodulin is found on endothelium of arteries, veins, capillaries, and lymphatics, and on syncytiotrophoblast of human placenta.

Authors:  I Maruyama; C E Bell; P W Majerus
Journal:  J Cell Biol       Date:  1985-08       Impact factor: 10.539

10.  Modulation of endothelial cell hemostatic properties by tumor necrosis factor.

Authors:  P P Nawroth; D M Stern
Journal:  J Exp Med       Date:  1986-03-01       Impact factor: 14.307
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  10 in total

1.  Role of NFkappaB in the mortality of sepsis.

Authors:  H Böhrer; F Qiu; T Zimmermann; Y Zhang; T Jllmer; D Männel; B W Böttiger; D M Stern; R Waldherr; H D Saeger; R Ziegler; A Bierhaus; E Martin; P P Nawroth
Journal:  J Clin Invest       Date:  1997-09-01       Impact factor: 14.808

2.  Intestinal Kaposi's sarcoma may mimic gastrointestinal stromal tumor in HIV infection.

Authors:  A Zoufaly; S Schmiedel; A W Lohse; J van Lunzen
Journal:  World J Gastroenterol       Date:  2007-09-07       Impact factor: 5.742

3.  Cytokines from activated T cells induce normal endothelial cells to acquire the phenotypic and functional features of AIDS-Kaposi's sarcoma spindle cells.

Authors:  V Fiorelli; R Gendelman; F Samaniego; P D Markham; B Ensoli
Journal:  J Clin Invest       Date:  1995-04       Impact factor: 14.808

Review 4.  Molecular genetics of Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) epidemiology and pathogenesis.

Authors:  Lyubomir A Dourmishev; Assen L Dourmishev; Diana Palmeri; Robert A Schwartz; David M Lukac
Journal:  Microbiol Mol Biol Rev       Date:  2003-06       Impact factor: 11.056

5.  Vascular endothelial growth factor and basic fibroblast growth factor present in Kaposi's sarcoma (KS) are induced by inflammatory cytokines and synergize to promote vascular permeability and KS lesion development.

Authors:  F Samaniego; P D Markham; R Gendelman; Y Watanabe; V Kao; K Kowalski; J A Sonnabend; A Pintus; R C Gallo; B Ensoli
Journal:  Am J Pathol       Date:  1998-06       Impact factor: 4.307

6.  Kaposin-B enhances the PROX1 mRNA stability during lymphatic reprogramming of vascular endothelial cells by Kaposi's sarcoma herpes virus.

Authors:  Jaehyuk Yoo; Jinjoo Kang; Ha Neul Lee; Berenice Aguilar; Darren Kafka; Sunju Lee; Inho Choi; Juneyong Lee; Swapnika Ramu; Juergen Haas; Chester J Koh; Young-Kwon Hong
Journal:  PLoS Pathog       Date:  2010-08-12       Impact factor: 6.823

7.  Coexistence of intestinal Kaposi sarcoma and plasmablastic lymphoma in an HIV/AIDS patient: case report and review of the literature.

Authors:  Bing Wang; Bingbing Song; Cyrus Oster; Jeffery Cao; Anwar Raza; Jun Wang
Journal:  J Gastrointest Oncol       Date:  2016-04

8.  Intravenous somatic gene transfer with antisense tissue factor restores blood flow by reducing tumor necrosis factor-induced tissue factor expression and fibrin deposition in mouse meth-A sarcoma.

Authors:  Y Zhang; Y Deng; T Wendt; B Liliensiek; A Bierhaus; J Greten; W He; B Chen; V Hach-Wunderle; R Waldherr; R Ziegler; D Männel; D M Stern; P P Nawroth
Journal:  J Clin Invest       Date:  1996-05-15       Impact factor: 14.808

9.  Expression of receptors for advanced glycation end products in peripheral occlusive vascular disease.

Authors:  U Ritthaler; Y Deng; Y Zhang; J Greten; M Abel; B Sido; J Allenberg; G Otto; H Roth; A Bierhaus
Journal:  Am J Pathol       Date:  1995-03       Impact factor: 4.307

10.  Human Mesenchymal Stem Cells of Diverse Origins Support Persistent Infection with Kaposi's Sarcoma-Associated Herpesvirus and Manifest Distinct Angiogenic, Invasive, and Transforming Phenotypes.

Authors:  Myung-Shin Lee; Hongfeng Yuan; Hyungtaek Jeon; Ying Zhu; Seungmin Yoo; Songtao Shi; Brian Krueger; Rolf Renne; Chun Lu; Jae U Jung; Shou-Jiang Gao
Journal:  mBio       Date:  2016-01-26       Impact factor: 7.867
  10 in total

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