Literature DB >> 7507240

First use of G-CSF in chlorpromazine-induced agranulocytosis: a report of two cases.

J R Kendra1, F P Rugman, T A Flaherty, A Myers, N Horsfield, A Barton, L Russell.   

Abstract

Chlorpromazine-induced agranulocytosis is an uncommon disorder associated with a high frequency of fatality. We describe two patients with chlorpromazine-induced granulocytosis in whom granulocyte colony stimulating factor (G-CSF) administration enhanced the speed of neutrophil recovery. No toxicity was noted with G-CSF and both patients made a successful recovery. We propose there is a role for such cytokine therapy in patients with life-threatening agranulocytosis in order to speed the recovery of neutrophils.

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Year:  1993        PMID： 7507240      PMCID： PMC2399942          DOI： 10.1136/pgmj.69.817.885

Source DB:  PubMed          Journal:  Postgrad Med J        ISSN： 0032-5473            Impact factor:   2.401


  6 in total

1.  Accelerated recovery from drug-induced agranulocytosis following G-CSF therapy.

Authors:  W N Patton; T L Holyoake; J M Yates; B J Boughton; I M Franklin
Journal:  Br J Haematol       Date:  1992-04       Impact factor: 6.998

2.  Granulocyte colony-stimulating factor for clozapine-induced agranulocytosis.

Authors:  S L Gerson; G Gullion; H S Yeh; C Masor
Journal:  Lancet       Date:  1992-10-31       Impact factor: 79.321

3.  Reduction by granulocyte colony-stimulating factor of fever and neutropenia induced by chemotherapy in patients with small-cell lung cancer.

Authors:  J Crawford; H Ozer; R Stoller; D Johnson; G Lyman; I Tabbara; M Kris; J Grous; V Picozzi; G Rausch
Journal:  N Engl J Med       Date:  1991-07-18       Impact factor: 91.245

4.  Successful treatment of clozapine induced agranulocytosis with granulocyte-colony stimulating factor (G-CSF).

Authors:  R Weide; H Köppler; J Heymanns; K H Pflüger; K Havemann
Journal:  Br J Haematol       Date:  1992-04       Impact factor: 6.998

5.  Drug-induced aplastic anaemia and agranulocytosis. Incidence and mechanisms.

Authors:  P C Vincent
Journal:  Drugs       Date:  1986-01       Impact factor: 9.546

6.  In vitro and in vivo analysis of the effects of recombinant human granulocyte colony-stimulating factor in patients.

Authors:  M H Bronchud; M R Potter; G Morgenstern; M J Blasco; J H Scarffe; N Thatcher; D Crowther; L M Souza; N K Alton; N G Testa
Journal:  Br J Cancer       Date:  1988-07       Impact factor: 7.640
  6 in total
  1 in total

Review 1.  Idiosyncratic drug-induced haematological abnormalities. Incidence, pathogenesis, management and avoidance.

Authors:  W N Patton; S B Duffull
Journal:  Drug Saf       Date:  1994-12       Impact factor: 5.606
  1 in total

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