| Literature DB >> 7507127 |
V S Byers1, E B Austin, J A Clegg, G Denton, B Gunn, D Hooi, F Hudecz, M R Price, R W Baldwin.
Abstract
Balb/c mice treated with an immunotoxin constructed by conjugation of murine monoclonal antibody 791T/36 via a disulfide linker to ricin A chain generate a pronounced antibody response to peptide epitopes on ricin A chain. Monoclonal anti-RTA antibodies which recognize peptide epitopes have been developed and these have been used to down-regulate anti-RTA antibody responses in 791T/36-RTA immunotoxin-treated Balb/c mice. Of the five MAB tests, two (608/7 and 596/134) proved most effective, inhibiting anti-RTA antibody formation by up to 73%. MAB treatment was effective when initiated up to 3 days after immunotoxin treatment. Pharmacokinetic studies with 791T/36-RTA have shown that the immunotoxin is rapidly eliminated from the circulation, with no more than 4% remaining in blood after 24 hr. It is proposed that the down-regulation of anti-RTA antibodies is effected by MAB interfering with antigen processing.Entities:
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Year: 1993 PMID： 7507127 DOI： 10.1007/bf00920016
Source DB: PubMed Journal: J Clin Immunol ISSN： 0271-9142 Impact factor: 8.317