Literature DB >> 7506663

Anti-emetic profile of a non-peptide neurokinin NK1 receptor antagonist, CP-99,994, in ferrets.

C Bountra1, K Bunce, T Dale, C Gardner, C Jordan, D Twissell, P Ward.   

Abstract

In the ferret, 5-HT3 receptor antagonists are effective in controlling emesis produced by cytotoxic agents or radiation. To investigate the possibility that substance P has a role, as well as 5-HT, in the emetic reflex pathway, we have examined the anti-emetic effects of a NK1 receptor antagonist (racemic CP-99,994) in the ferret. Racemic CP-99,994 was effective against a range of emetogens, comprising cytotoxic drugs, radiation, morphine, ipecacuanha and copper sulphate.

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Year:  1993        PMID： 7506663     DOI： 10.1016/0014-2999(93)90673-6

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  27 in total

1.  Integrative responses of neurons in parabrachial nuclei to a nauseogenic gastrointestinal stimulus and vestibular stimulation in vertical planes.

Authors:  Takeshi Suzuki; Yoichiro Sugiyama; Bill J Yates
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2012-01-25       Impact factor: 3.619

2.  Mechanism of the prostanoid TP receptor agonist U46619 for inducing emesis in the ferret.

Authors:  Kelvin K W Kan; Man P Ngan; Man K Wai; John A Rudd
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2008-07-11       Impact factor: 3.000

3.  Integrative responses of neurons in nucleus tractus solitarius to visceral afferent stimulation and vestibular stimulation in vertical planes.

Authors:  Yoichiro Sugiyama; Takeshi Suzuki; Vincent J DeStefino; Bill J Yates
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2011-08-10       Impact factor: 3.619

4.  Corticosteroids, the oldest agent in the prevention of chemotherapy-induced nausea and vomiting: What about the guidelines?

Authors:  Florence Van Ryckeghem
Journal:  J Transl Int Med       Date:  2016-04-14

5.  A pharmacophore model for NK2 antagonist comprising compounds from several structurally diverse classes.

Authors:  Anders Poulsen; Tommy Liljefors; Klaus Gundertofte; Berith Bjørnholm
Journal:  J Comput Aided Mol Des       Date:  2002-04       Impact factor: 3.686

6.  The emetic and anti-emetic effects of the capsaicin analogue resiniferatoxin in Suncus murinus, the house musk shrew.

Authors:  P L Andrews; F Okada; A J Woods; H Hagiwara; S Kakaimoto; M Toyoda; N Matsuki
Journal:  Br J Pharmacol       Date:  2000-07       Impact factor: 8.739

7.  Effects of visceral inputs on the processing of labyrinthine signals by the inferior and caudal medial vestibular nuclei: ramifications for the production of motion sickness.

Authors:  Milad S Arshian; Sonya R Puterbaugh; Daniel J Miller; Michael F Catanzaro; Candace E Hobson; Andrew A McCall; Bill J Yates
Journal:  Exp Brain Res       Date:  2013-05-28       Impact factor: 1.972

8.  Chemotherapy-induced kaolin intake is increased by lesion of the lateral parabrachial nucleus of the rat.

Authors:  Charles C Horn; Bart C De Jonghe; Kathleen Matyas; Ralph Norgren
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2009-08-26       Impact factor: 3.619

Review 9.  Antiemetic therapy options for chemotherapy-induced nausea and vomiting in breast cancer patients.

Authors:  Vicky Tc Chan; Winnie Yeo
Journal:  Breast Cancer (Dove Med Press)       Date:  2011-11-14

10.  Building a better analgesic: multifunctional compounds that address injury-induced pathology to enhance analgesic efficacy while eliminating unwanted side effects.

Authors:  T M Largent-Milnes; S W Brookshire; D P Skinner; K E Hanlon; D Giuvelis; T Yamamoto; P Davis; C R Campos; P Nair; S Deekonda; E J Bilsky; F Porreca; V J Hruby; T W Vanderah
Journal:  J Pharmacol Exp Ther       Date:  2013-07-16       Impact factor: 4.030
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