Literature DB >> 7506406

Cytoskeleton-associated antigens from African trypanosomes are recognized by self-reactive antibodies of uninfected mice.

N Müller1, M Imboden, E Detmer, J M Mansfield, T Seebeck.   

Abstract

Serum from uninfected mice of different strains, as well as from germ-free animals, contains antibodies which react specifically with at least two trypanosomal proteins, I/6 and MARP1. These antibody populations are highly specific for the respective proteins, are of similar affinity as hyperimmune antibodies, and consist of IgM as well as IgG isotypes. Hyperimmune antibody raised against the cross-reacting trypanosomal protein I/6 detects a 60 kDa protein in mouse 3T6 cells, which is a component of the fibroblast cytoskeleton.

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Year:  1993        PMID： 7506406     DOI： 10.1017/s0031182000067767

Source DB:  PubMed          Journal:  Parasitology        ISSN： 0031-1820            Impact factor:   3.234


  8 in total

1.  Comparative analysis of antibody responses against HSP60, invariant surface glycoprotein 70, and variant surface glycoprotein reveals a complex antigen-specific pattern of immunoglobulin isotype switching during infection by Trypanosoma brucei.

Authors:  M Radwanska; S Magez; A Michel; B Stijlemans; M Geuskens; E Pays
Journal:  Infect Immun       Date:  2000-02       Impact factor: 3.441

2.  Trypanosome variant surface glycoproteins are recognized by self-reactive antibodies in uninfected hosts.

Authors:  N Müller; J M Mansfield; T Seebeck
Journal:  Infect Immun       Date:  1996-11       Impact factor: 3.441

3.  Interleukin-4-dependent immunoglobulin G1 isotype switch in the presence of a polarized antigen-specific Th1-cell response to the trypanosome variant surface glycoprotein.

Authors:  L R Schopf; H Filutowicz; X J Bi; J M Mansfield
Journal:  Infect Immun       Date:  1998-02       Impact factor: 3.441

4.  Control of experimental Trypanosoma brucei infections occurs independently of lymphotoxin-alpha induction.

Authors:  S Magez; B Stijlemans; G Caljon; H-P Eugster; P De Baetselier
Journal:  Infect Immun       Date:  2002-03       Impact factor: 3.441

5.  A search for Trypanosoma brucei rhodesiense diagnostic antigens by proteomic screening and targeted cloning.

Authors:  Theresa Manful; Julius Mulindwa; Fernanda M Frank; Christine E Clayton; Enock Matovu
Journal:  PLoS One       Date:  2010-03-10       Impact factor: 3.240

6.  The orthologue of Sjögren's syndrome nuclear autoantigen 1 (SSNA1) in Trypanosoma brucei is an immunogenic self-assembling molecule.

Authors:  Helen P Price; Michael R Hodgkinson; Rachel S Curwen; Lorna M MacLean; James A Brannigan; Mark Carrington; Barbara A Smith; David A Ashford; Meg Stark; Deborah F Smith
Journal:  PLoS One       Date:  2012-02-20       Impact factor: 3.240

7.  Evaluation of Antigens for Development of a Serological Test for Human African Trypanosomiasis.

Authors:  Sylvain Biéler; Harald Waltenberger; Michael P Barrett; Richard McCulloch; Jeremy C Mottram; Mark Carrington; Wilhelm Schwaeble; James McKerrow; Margaret A Phillips; Paul A Michels; Philippe Büscher; Jean-Charles Sanchez; Richard Bishop; Derrick R Robinson; James Bangs; Michael Ferguson; Barbara Nerima; Audrey Albertini; Gerd Michel; Magdalena Radwandska; Joseph Mathu Ndung'u
Journal:  PLoS One       Date:  2016-12-09       Impact factor: 3.240

8.  The Lipid Raft Proteome of African Trypanosomes Contains Many Flagellar Proteins.

Authors:  Aabha I Sharma; Cheryl L Olson; David M Engman
Journal:  Pathogens       Date:  2017-08-24
  8 in total

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