Literature DB >> 7506268

Pulsatile release of gonadotrophin releasing hormone (GnRH) is an intrinsic property of GT1 GnRH neuronal cell lines.

R I Weiner1, G Martinez de la Escalera.   

Abstract

The GT1-1 gonadotrophin releasing hormone (GnRH) cell line releases GnRH in a pulsatile fashion. This finding demonstrates that the generation and synchronization of GnRH pulses is an intrinsic property of GnRH neurons. It appears that propagated action potentials and a Ca(2+)-coupled secretory mechanism are necessary for pulsatile release. The secretion of GnRH from GT1 cells is stimulated by both norepinephrine and dopamine respectively via beta 1-adrenergic and D1-dopaminergic receptors. These findings provide new data for the understanding of the complex neuroendocrine regulation of luteinizing hormone.

Entities:  

Mesh：

Substances：

Year:  1993        PMID： 7506268     DOI： 10.1093/humrep/8.suppl_2.13

Source DB:  PubMed          Journal:  Hum Reprod        ISSN： 0268-1161            Impact factor:   6.918


  8 in total

1.  Orexin A induces GnRH gene expression and secretion from GT1-7 hypothalamic GnRH neurons.

Authors:  Ravid Sasson; Robert K Dearth; Rachel S White; Patrick E Chappell; Pamela L Mellon
Journal:  Neuroendocrinology       Date:  2006-12-28       Impact factor: 4.914

2.  Cross-talk between luteinizing hormone-releasing hormone (LHRH) neurons and astroglial cells: developing glia release factors that accelerate neuronal differentiation and stimulate LHRH release from GT(1-1) neuronal cell line and LHRH neurons induce astroglia proliferation.

Authors:  F Gallo; M C Morale; R Avola; B Marchetti
Journal:  Endocrine       Date:  1995-12       Impact factor: 3.633

Review 3.  Modulating mechanisms of neuroendocrine cell activity: the LHRH pulse generator.

Authors:  F J López; I J Merchenthaler; M Moretto; A Negro-Vilar
Journal:  Cell Mol Neurobiol       Date:  1998-02       Impact factor: 5.046

4.  Circadian gene expression regulates pulsatile gonadotropin-releasing hormone (GnRH) secretory patterns in the hypothalamic GnRH-secreting GT1-7 cell line.

Authors:  Patrick E Chappell; Rachel S White; Pamela L Mellon
Journal:  J Neurosci       Date:  2003-12-03       Impact factor: 6.167

5.  Estrogen regulation of gene expression in GnRH neurons.

Authors:  Yewade Ng; Andrew Wolfe; Horacio J Novaira; Sally Radovick
Journal:  Mol Cell Endocrinol       Date:  2009-02-02       Impact factor: 4.102

6.  A progesterone metabolite stimulates the release of gonadotropin-releasing hormone from GT1-1 hypothalamic neurons via the gamma-aminobutyric acid type A receptor.

Authors:  M el-Etr; Y Akwa; R J Fiddes; P Robel; E E Baulieu
Journal:  Proc Natl Acad Sci U S A       Date:  1995-04-25       Impact factor: 11.205

Review 7.  The hypothalamic GnRH pulse generator: multiple regulatory mechanisms.

Authors:  Lazar Z Krsmanovic; Lian Hu; Po-Ki Leung; Hao Feng; Kevin J Catt
Journal:  Trends Endocrinol Metab       Date:  2009-09-07       Impact factor: 12.015

8.  A Novel Gonadotropin-Releasing Hormone 1 (Gnrh1) Enhancer-Derived Noncoding RNA Regulates Gnrh1 Gene Expression in GnRH Neuronal Cell Models.

Authors:  Polly P Huang; Liza E Brusman; Anita K Iyer; Nicholas J G Webster; Pamela L Mellon
Journal:  PLoS One       Date:  2016-07-07       Impact factor: 3.240
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.