Literature DB >> 7506122

Potential use of soluble CD44 in serum as indicator of tumor burden and metastasis in patients with gastric or colon cancer.

Y J Guo1, G Liu, X Wang, D Jin, M Wu, J Ma, M S Sy.   

Abstract

Soluble CD44 is present in the serum of normal individuals (2.7 +/- 1.1 nM). The concentration of soluble CD44 in the serum is elevated in patients with advanced gastric (24.2 +/- 9.8 nM) or colon cancer (30.8 +/- 11 nM). Serum CD44 concentration correlated with tumor metastasis and tumor burden. Surgical resection of tumors resulted in decreases in serum CD44 levels. By Western blot analysis, monoclonal anti-CD44 antibody reacted with a major protein with molecular weight between 130,000 and 190,000. In addition, two proteins with molecular weights of 72,000 and 80,000 can also be identified. Therefore, different CD44 isoforms may be present in the serum of cancer patients. Serum CD44 concentrations may be an indicator of tumor burden and metastasis in patients with malignant diseases.

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Year:  1994        PMID： 7506122

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  43 in total

1.  Identification and characterization of CD44RC, a novel alternatively spliced soluble CD44 isoform that can potentiate the hyaluronan binding activity of cell surface CD44.

Authors:  R K Chiu; C Carpenito; S T Dougherty; G M Hayes; G J Dougherty
Journal:  Neoplasia       Date:  1999-11       Impact factor: 5.715

2.  Detection of exfoliated carcinoma cells in colonic luminal washings by identification of deranged patterns of expression of the CD44 gene.

Authors:  K Yoshida; T Sugino; J Bolodeoku; B F Warren; S Goodison; A Woodman; T Toge; E Tahara; D Tarin
Journal:  J Clin Pathol       Date:  1996-04       Impact factor: 3.411

3.  Cluster of Differentiation 44 (CD44) Gene Variants: A Putative Cancer Stem Cell Marker in Risk Prediction of Bladder Cancer in North Indian Population.

Authors:  Archana Verma; Rakesh Kapoor; Rama Devi Mittal
Journal:  Indian J Clin Biochem       Date:  2016-05-21

4.  Intracellular domain fragment of CD44 alters CD44 function in chondrocytes.

Authors:  Liliana Mellor; Cheryl B Knudson; Daisuke Hida; Emily B Askew; Warren Knudson
Journal:  J Biol Chem       Date:  2013-07-24       Impact factor: 5.157

5.  Evaluation of soluble CD44 protein marker to distinguish the premalignant and malignant carcinoma cases in cervical cancer patients.

Authors:  Subramanyam Dasari; Wudayagiri Rajendra; Lokanatha Valluru
Journal:  Med Oncol       Date:  2014-07-27       Impact factor: 3.064

6.  Pigment epithelium-derived factor binds to hyaluronan. Mapping of a hyaluronan binding site.

Authors:  S Patricia Becerra; L Alberto Perez-Mediavilla; John E Weldon; Silvia Locatelli-Hoops; Preenie Senanayake; Luigi Notari; Vicente Notario; Joe G Hollyfield
Journal:  J Biol Chem       Date:  2008-09-19       Impact factor: 5.157

7.  Poor diagnostic value of colonic CD44v6 expression and serum concentrations of its soluble form in the differentiation of ulcerative colitis from Crohn's disease.

Authors:  W Reinisch; K H Heider; G Oberhuber; C Dejaco; M Müllner; G R Adolf; C Gasché
Journal:  Gut       Date:  1998-09       Impact factor: 23.059

Review 8.  Demystified ... adhesion molecules.

Authors:  A J Freemont
Journal:  Mol Pathol       Date:  1998-08

9.  CD44 standard form expression as a predictor of progression in high risk superficial bladder tumors.

Authors:  N E Stavropoulos; I Filliadis; E Ioachim; M Michael; E Mermiga; K Hastazeris; U O Nseyo
Journal:  Int Urol Nephrol       Date:  2001       Impact factor: 2.370

10.  Blood classical monocytes phenotype is not altered in primary non-small cell lung cancer.

Authors:  Saleh A Almatroodi; Christine F McDonald; Allison L Collins; Ian A Darby; Dodie S Pouniotis
Journal:  World J Clin Oncol       Date:  2014-12-10
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