| Literature DB >> 7506033 |
U Galili1.
Abstract
Cells of nonprimate mammals express an abundance of the carbohydrate structure Gal alpha 1-3 Gal beta 1-4 GlcNac-R (termed the alpha-galactosyl epitope). The natural anti-Gal antibody, which interacts specifically with alpha-galactosyl epitopes, is present in high concentrations in all humans. Here, Uri Galili argues that the interaction between anti-Gal in the serum and alpha-galactosyl epitopes on cells of nonprimate grafts may act as an immunological barrier which prevents xenotransplantation.Entities:
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Year: 1993 PMID： 7506033 DOI： 10.1016/0167-5699(93)90261-i
Source DB: PubMed Journal: Immunol Today ISSN： 0167-5699