Literature DB >> 7505952

The Met proto-oncogene mesenchymal to epithelial cell conversion.

I Tsarfaty1, S Rong, J H Resau, S Rulong, P P da Silva, G F Vande Woude.   

Abstract

Coexpression of the human Met receptor and its ligand, hepatocyte growth factor/scatter factor (HGF/SF), in NIH 3T3 fibroblasts causes the cells to become tumorigenic in nude mice. The resultant tumors display lumen-like morphology, contain carcinoma-like focal areas with intercellular junctions resembling desmosomes, and coexpress epithelial (cytokeratin) and mesenchymal (vimentin) cytoskeletal markers. The tumor cells also display enhanced expression of desmosomal and tight-junction proteins. The apparent mesenchymal to epithelial conversion of the tumor cells mimics the conversion that occurs during embryonic kidney development, suggesting that Met-HGF/SF signaling plays a role in this process as well as in tumors that express both epithelial and mesenchymal markers.

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Year:  1994        PMID： 7505952     DOI： 10.1126/science.7505952

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  54 in total

1.  Scatter factor/hepatocyte growth factor as a regulator of skeletal muscle and neural crest development.

Authors:  H Takayama; W J La Rochelle; M Anver; D E Bockman; G Merlino
Journal:  Proc Natl Acad Sci U S A       Date:  1996-06-11       Impact factor: 11.205

2.  In vivo direct molecular imaging of early tumorigenesis and malignant progression induced by transgenic expression of GFP-Met.

Authors:  Sharon Moshitch-Moshkovitz; Galia Tsarfaty; Dafna W Kaufman; Gideon Y Stein; Keren Shichrur; Eddy Solomon; Robert H Sigler; James H Resau; George F Vande Woude; Ilan Tsarfaty
Journal:  Neoplasia       Date:  2006-05       Impact factor: 5.715

3.  The von Hippel-Lindau tumor suppressor gene inhibits hepatocyte growth factor/scatter factor-induced invasion and branching morphogenesis in renal carcinoma cells.

Authors:  S Koochekpour; M Jeffers; P H Wang; C Gong; G A Taylor; L M Roessler; R Stearman; J R Vasselli; W G Stetler-Stevenson; W G Kaelin; W M Linehan; R D Klausner; J R Gnarra; G F Vande Woude
Journal:  Mol Cell Biol       Date:  1999-09       Impact factor: 4.272

4.  Degradation of the Met tyrosine kinase receptor by the ubiquitin-proteasome pathway.

Authors:  M Jeffers; G A Taylor; K M Weidner; S Omura; G F Vande Woude
Journal:  Mol Cell Biol       Date:  1997-02       Impact factor: 4.272

5.  Diverse tumorigenesis associated with aberrant development in mice overexpressing hepatocyte growth factor/scatter factor.

Authors:  H Takayama; W J LaRochelle; R Sharp; T Otsuka; P Kriebel; M Anver; S A Aaronson; G Merlino
Journal:  Proc Natl Acad Sci U S A       Date:  1997-01-21       Impact factor: 11.205

6.  Basic fibroblast growth factor can mediate the early inductive events in renal development.

Authors:  A O Perantoni; L F Dove; I Karavanova
Journal:  Proc Natl Acad Sci U S A       Date:  1995-05-09       Impact factor: 11.205

7.  Invasiveness and metastasis of NIH 3T3 cells induced by Met-hepatocyte growth factor/scatter factor autocrine stimulation.

Authors:  S Rong; S Segal; M Anver; J H Resau; G F Vande Woude
Journal:  Proc Natl Acad Sci U S A       Date:  1994-05-24       Impact factor: 11.205

Review 8.  MET as a target for treatment of chest tumors.

Authors:  Nicole A Cipriani; Oyewale O Abidoye; Everett Vokes; Ravi Salgia
Journal:  Lung Cancer       Date:  2008-07-30       Impact factor: 5.705

9.  Role of HGF/c-Met in serum-starved ARPE-19 cells.

Authors:  Eun Jung Jun; Hwa Sun Kim; Yeong Hoon Kim
Journal:  Korean J Ophthalmol       Date:  2007-12

10.  Transdifferentiation-inducing HCCR-1 oncogene.

Authors:  Seon-Ah Ha; Hyun K Kim; JinAh Yoo; SangHee Kim; Seung M Shin; Youn S Lee; Soo Y Hur; Yong W Kim; Tae E Kim; Yeun J Chung; Shin S Jeun; Dong W Kim; Yong G Park; Jin Kim; Soon Y Shin; Young H Lee; Jin W Kim
Journal:  BMC Cell Biol       Date:  2010-06-30       Impact factor: 4.241
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