Literature DB >> 7505569

Insect immunity: the diptericin promoter contains multiple functional regulatory sequences homologous to mammalian acute-phase response elements.

P Georgel1, M Meister, C Kappler, B Lemaitre, J M Reichhart, J A Hoffmann.   

Abstract

We are using the diptericin gene as a model system to study the control of expression of the genes encoding antibacterial peptides during the Drosophila immune reaction. In order to investigate the putative regulatory regions in the diptericin promoter, we performed DNaseI footprinting experiments combined with gel-shift assays in two inducible systems: the larval fat body and a tumorous Drosophila blood cell line. Our results confirm the importance of kappa B-like elements previously described in the immune response of insects and reveal for the first time the involvement of other regions containing sequences homologous to mammalian acute-phase response elements.

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Year:  1993        PMID： 7505569     DOI： 10.1006/bbrc.1993.2508

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  15 in total

1.  The 18-wheeler mutation reveals complex antibacterial gene regulation in Drosophila host defense.

Authors:  M J Williams; A Rodriguez; D A Kimbrell; E D Eldon
Journal:  EMBO J       Date:  1997-10-15       Impact factor: 11.598

2.  A kappaB sequence code for pathway-specific innate immune responses.

Authors:  Matthew S Busse; Christopher P Arnold; Par Towb; James Katrivesis; Steven A Wasserman
Journal:  EMBO J       Date:  2007-07-26       Impact factor: 11.598

3.  A conserved p38 mitogen-activated protein kinase pathway regulates Drosophila immunity gene expression.

Authors:  Z S Han; H Enslen; X Hu; X Meng; I H Wu; T Barrett; R J Davis; Y T Ip
Journal:  Mol Cell Biol       Date:  1998-06       Impact factor: 4.272

4.  Drosophila immunity. A sequence homologous to mammalian interferon consensus response element enhances the activity of the diptericin promoter.

Authors:  P Georgel; C Kappler; E Langley; I Gross; E Nicolas; J M Reichhart; J A Hoffmann
Journal:  Nucleic Acids Res       Date:  1995-04-11       Impact factor: 16.971

5.  Genomic structure and ecdysone regulation of the prophenoloxidase 1 gene in the malaria vector Anopheles gambiae.

Authors:  A Ahmed; D Martín; A G Manetti; S J Han; W J Lee; K D Mathiopoulos; H M Müller; F C Kafatos; A Raikhel; P T Brey
Journal:  Proc Natl Acad Sci U S A       Date:  1999-12-21       Impact factor: 11.205

6.  Immune factor Gambif1, a new rel family member from the human malaria vector, Anopheles gambiae.

Authors:  C Barillas-Mury; A Charlesworth; I Gross; A Richman; J A Hoffmann; F C Kafatos
Journal:  EMBO J       Date:  1996-09-02       Impact factor: 11.598

7.  A recessive mutation, immune deficiency (imd), defines two distinct control pathways in the Drosophila host defense.

Authors:  B Lemaitre; E Kromer-Metzger; L Michaut; E Nicolas; M Meister; P Georgel; J M Reichhart; J A Hoffmann
Journal:  Proc Natl Acad Sci U S A       Date:  1995-10-10       Impact factor: 11.205

8.  Drosophila immunity: a comparative analysis of the Rel proteins dorsal and Dif in the induction of the genes encoding diptericin and cecropin.

Authors:  I Gross; P Georgel; C Kappler; J M Reichhart; J A Hoffmann
Journal:  Nucleic Acids Res       Date:  1996-04-01       Impact factor: 16.971

9.  A novel association between clustered NF-kappaB and C/EBP binding sites is required for immune regulation of mosquito Defensin genes.

Authors:  J M Meredith; R J L Munks; W Grail; H Hurd; P Eggleston; M J Lehane
Journal:  Insect Mol Biol       Date:  2006-08       Impact factor: 3.585

Review 10.  NF-κB/Rel proteins and the humoral immune responses of Drosophila melanogaster.

Authors:  Sandhya Ganesan; Kamna Aggarwal; Nicholas Paquette; Neal Silverman
Journal:  Curr Top Microbiol Immunol       Date:  2011       Impact factor: 4.291
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