| Literature DB >> 7505005 |
A Hoshioka1, Y Kohno, T Katsuki, N Shimojo, N Maruyama, Y Inagaki, T Yokochi, O Tarutani, T Hosoya, H Niimi.
Abstract
We have investigated functional common T-cell epitopes between human thyroglobulin (hTg) and human thyroid peroxidase (hTPO) in mice. Four hTg peptides, Tg-P1, Tg-P2, Tg-P3 and Tg-P4, in which 5 amino acid residues are identical to those of hTPO, and 1 hTPO peptide, TPO-P4 relevant to Tg-P4, were prepared. Among these peptides, only Tg-P4 (residues 2730-2743) and TPO-P4 (residues 118-131) were highly antigenic and both peptides shared the common T-cell epitope. In addition, when the spleen cells from mice immunized with mouse Tg (mTg) were restimulated in vitro by Tg-P4 or TPO-P4 as well as by mTg, these cells transferred thyroiditis to naive recipient mice. These findings indicate that this common T-cell epitope between hTg and hTPO is immunogenic and related to the development of murine experimental autoimmune thyroiditis.Entities:
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Year: 1993 PMID： 7505005 DOI： 10.1016/0165-2478(93)90036-2
Source DB: PubMed Journal: Immunol Lett ISSN： 0165-2478 Impact factor: 3.685