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Literature DB >> 7504541

Expression of human endogenous retrovirus (HERV-K) in chronic myeloid leukemia.

Abstract

We have previously demonstrated the presence of a reverse transcriptase-like enzyme in retroviral particles from patients with essential thrombocythemia, polycythemia vera, and chronic myelogenous leukemia. It was subsequently shown that the human genome contains 50 copies of HERV-K. HERV-K is a human endogenous class I retroviral element that contains gag, pol, and env open reading frames. Using both reverse transcriptase-polymerase chain reaction and ribonuclease protection assays, it is demonstrated that the HERV-K pol is expressed in human blood leukocytes. The data indicates that this expression is restricted in CML white cells and is the result of gene regulation.

Entities: Disease Gene Species

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Year: 1993 PMID： 7504541 DOI： 10.3109/10428199309047874

Source DB: PubMed Journal: Leuk Lymphoma ISSN： 1026-8022

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Cited

11 in total

1. Elevated HERV-K mRNA expression in PBMC is associated with a prostate cancer diagnosis particularly in older men and smokers.

Authors: Tiffany A Wallace; Ronan F Downey; Caleb J Seufert; Aaron Schetter; Tiffany H Dorsey; Carol A Johnson; Radoslav Goldman; Christopher A Loffredo; Peisha Yan; Francis J Sullivan; Francis J Giles; Feng Wang-Johanning; Stefan Ambs; Sharon A Glynn
Journal: Carcinogenesis Date: 2014-05-23 Impact factor: 4.944

2. The promoter activity of long terminal repeats of the HERV-H family of human retrovirus-like elements is critically dependent on Sp1 family proteins interacting with a GC/GT box located immediately 3' to the TATA box.

Authors: E Sjøttem; S Anderssen; T Johansen
Journal: J Virol Date: 1996-01 Impact factor: 5.103

3. Genomic flexibility of human endogenous retrovirus type K.

Authors: Derek Dube; Rafael Contreras-Galindo; Shirley He; Steven R King; Marta J Gonzalez-Hernandez; Scott D Gitlin; Mark H Kaplan; David M Markovitz
Journal: J Virol Date: 2014-06-11 Impact factor: 5.103

4. Germ cell expression of an isolated human endogenous retroviral long terminal repeat of the HERV-K/HTDV family in transgenic mice.

Authors: A E Casau; J E Vaughan; G Lozano; A J Levine
Journal: J Virol Date: 1999-12 Impact factor: 5.103

5. Human endogenous retrovirus W env increases nitric oxide production and enhances the migration ability of microglia by regulating the expression of inducible nitric oxide synthase.

Authors: Ran Xiao; Shan Li; Qian Cao; Xiuling Wang; Qiujin Yan; Xiaoning Tu; Ying Zhu; Fan Zhu
Journal: Virol Sin Date: 2017-06-23 Impact factor: 4.327

Expression of human endogenous retrovirus (HERV-K) in chronic myeloid leukemia.

1. Elevated HERV-K mRNA expression in PBMC is associated with a prostate cancer diagnosis particularly in older men and smokers.

2. The promoter activity of long terminal repeats of the HERV-H family of human retrovirus-like elements is critically dependent on Sp1 family proteins interacting with a GC/GT box located immediately 3' to the TATA box.

3. Genomic flexibility of human endogenous retrovirus type K.

4. Germ cell expression of an isolated human endogenous retroviral long terminal repeat of the HERV-K/HTDV family in transgenic mice.

5. Human endogenous retrovirus W env increases nitric oxide production and enhances the migration ability of microglia by regulating the expression of inducible nitric oxide synthase.

6. Two groups of endogenous MMTV related retroviral env transcripts expressed in human tissues.

7. Distribution of human endogenous retrovirus HERV-K genomes in humans and different primates.

8. Virome characterisation from Guthrie cards in children who later developed acute lymphoblastic leukaemia.

Review 9. Human RNA "rumor" viruses: the search for novel human retroviruses in chronic disease.

10. Elevated HERV-K Expression in Soft Tissue Sarcoma Is Associated with Worsened Relapse-Free Survival.