BACKGROUND: Whether leanness is related to an increased risk of lung cancer is controversial. OBJECTIVE: To examine the association of leanness with lung cancer incidence in a sample of Israeli men. METHODS: The 23-year lung cancer incidence (1963 through 1986) was determined by linkage to the Israel Cancer Registry in 9975 male civil servants aged 40 through 69 years at initial examination in 1963. In 198,298 person-years of follow-up, 153 cases of lung cancer were identified. In 1963, body mass index (BMI) and cigarette smoking status were determined; in the 1968 reexamination, lung function tests were performed and BMI was reassessed. RESULTS: Adjusted for age, smoking, and city by Cox regression, BMI was exponentially inversely related to lung cancer incidence, with a relative risk of 2.3 (95% confidence interval [CI], 1.4 to 3.8) comparing the lowest fifth of BMI (< 22.93 kg/m2) with the highest. The association was evident in light, moderate, and heavy smokers. Among smokers, the adjusted relative risk was 3.7 (95% CI, 1.9 to 7.3) for the lowest fifth of BMI. The associations were stronger for men in the lowest 10th of the BMI distribution (< 21.38 kg/m2). Controlling for lung function did not materially change the results. The adjusted population-attributable fraction associated with the lowest fifth of BMI among smokers was 20.4% (95% CI, 10.1% to 29.9%). Survival analysis showed that the association of BMI with lung cancer persisted throughout follow-up. CONCLUSIONS: The association shown between thinness and lung cancer incidence, particularly in smokers, was not attributable to the confounding factors studied, preclinical weight loss, or competing risks. Thinness in smokers may lead to, or may reflect, enhanced host susceptibility.
BACKGROUND: Whether leanness is related to an increased risk of lung cancer is controversial. OBJECTIVE: To examine the association of leanness with lung cancer incidence in a sample of Israeli men. METHODS: The 23-year lung cancer incidence (1963 through 1986) was determined by linkage to the Israel Cancer Registry in 9975 male civil servants aged 40 through 69 years at initial examination in 1963. In 198,298 person-years of follow-up, 153 cases of lung cancer were identified. In 1963, body mass index (BMI) and cigarette smoking status were determined; in the 1968 reexamination, lung function tests were performed and BMI was reassessed. RESULTS: Adjusted for age, smoking, and city by Cox regression, BMI was exponentially inversely related to lung cancer incidence, with a relative risk of 2.3 (95% confidence interval [CI], 1.4 to 3.8) comparing the lowest fifth of BMI (< 22.93 kg/m2) with the highest. The association was evident in light, moderate, and heavy smokers. Among smokers, the adjusted relative risk was 3.7 (95% CI, 1.9 to 7.3) for the lowest fifth of BMI. The associations were stronger for men in the lowest 10th of the BMI distribution (< 21.38 kg/m2). Controlling for lung function did not materially change the results. The adjusted population-attributable fraction associated with the lowest fifth of BMI among smokers was 20.4% (95% CI, 10.1% to 29.9%). Survival analysis showed that the association of BMI with lung cancer persisted throughout follow-up. CONCLUSIONS: The association shown between thinness and lung cancer incidence, particularly in smokers, was not attributable to the confounding factors studied, preclinical weight loss, or competing risks. Thinness in smokers may lead to, or may reflect, enhanced host susceptibility.
Authors: Gabriella Andreotti; Lifang Hou; Laura E Beane Freeman; Rajeev Mahajan; Stella Koutros; Joseph Coble; Jay Lubin; Aaron Blair; Jane A Hoppin; Michael Alavanja Journal: Cancer Causes Control Date: 2010-08-22 Impact factor: 2.506
Authors: C Martin Tammemagi; Paul F Pinsky; Neil E Caporaso; Paul A Kvale; William G Hocking; Timothy R Church; Thomas L Riley; John Commins; Martin M Oken; Christine D Berg; Philip C Prorok Journal: J Natl Cancer Inst Date: 2011-05-23 Impact factor: 13.506
Authors: Heather P Tarleton; Sungshim Lani Park; Wei-Ming Zhu; Yuan-Chin Amy Lee; Mia Hashibe; Hal Morgenstern; Donald P Tashkin; Jenny T Mao; Wendy Cozen; Thomas M Mack; Zuo-Feng Zhang Journal: Int J Cancer Date: 2012-02-09 Impact factor: 7.396
Authors: Llewellyn Smith; Louise A Brinton; Margaret R Spitz; Tram Kim Lam; Yikyung Park; Albert R Hollenbeck; Neal D Freedman; Gretchen L Gierach Journal: J Natl Cancer Inst Date: 2012-03-27 Impact factor: 13.506
Authors: Mia M Gaudet; Andrew F Olshan; Shu-Chun Chuang; Julien Berthiller; Zuo-Feng Zhang; Jolanta Lissowska; David Zaridze; Deborah M Winn; Qingyi Wei; Renato Talamini; Neolilia Szeszenia-Dabrowska; Erich M Sturgis; Stephen M Schwartz; Peter Rudnai; Jose Eluf-Neto; Joshua Muscat; Hal Morgenstern; Ana Menezes; Elena Matos; Alexandru Bucur; Fabio Levi; Philip Lazarus; Carlo La Vecchia; Sergio Koifman; Karl Kelsey; Rolando Herrero; Richard B Hayes; Silva Franceschi; Victor Wunsch-Filho; Leticia Fernandez; Eleonora Fabianova; Alexander W Daudt; Luigino Dal Maso; Maria Paula Curado; Chu Chen; Xavier Castellsague; Simone Benhamou; Paolo Boffetta; Paul Brennan; Mia Hashibe Journal: Int J Epidemiol Date: 2010-02-01 Impact factor: 7.196