Indications for examination of spontaneous abortion specimens: a reassessment.

The clinical evaluation of recurrent pregnancy loss is assessed in light of recent technical advances in trophoblast culture, ultrasonography, and chromosome analysis. With an algorithm based on karyotype results, cost-benefit calculations confirm that an average savings of $1099.47 per patient could be achieved if a policy of karyotype analysis of recurrent abortion specimens was emphasized. It is estimated that a specific chromosomal cause could be identified in 45% to 70% of such cases. A more concerted effort should be made to culture trophoblast tissue from recurrent pregnancy losses; such a policy would result in both emotional and financial rewards.