BACKGROUND AND OBJECTIVES: Fluoroquinolones are widely used oral agents for treating Neisseria gonorrhoeae. Resistance to these agents is sporadic and usually at a low level. Two instances of high-dose ciprofloxacin regimens failing in the treatment of gonococcal infection, caused by strains with high-level quinolone resistance, are reported. STUDY DESIGN: This is a case report. CONCLUSION: High-level resistance to quinolone antibiotics resulting in treatment failure was observed in two distinct gonococcal isolates from patients infected in the Philippines (ciprofloxacin; minimal inhibitory contribution = 16 mg/l). Continued monitoring of the quinolone sensitivity of Neisseria gonorrhoeae is appropriate and prudent.
BACKGROUND AND OBJECTIVES:Fluoroquinolones are widely used oral agents for treating Neisseria gonorrhoeae. Resistance to these agents is sporadic and usually at a low level. Two instances of high-dose ciprofloxacin regimens failing in the treatment of gonococcal infection, caused by strains with high-level quinolone resistance, are reported. STUDY DESIGN: This is a case report. CONCLUSION: High-level resistance to quinolone antibiotics resulting in treatment failure was observed in two distinct gonococcal isolates from patients infected in the Philippines (ciprofloxacin; minimal inhibitory contribution = 16 mg/l). Continued monitoring of the quinolone sensitivity of Neisseria gonorrhoeae is appropriate and prudent.
Authors: T Deguchi; M Yasuda; M Nakano; E Kanematsu; S Ozeki; Y Nishino; T Ezaki; S Maeda; I Saito; Y Kawada Journal: J Clin Microbiol Date: 1997-04 Impact factor: 5.948
Authors: Ana Paula Ramalho da Costa-Lourenço; Késia Thaís Barros Dos Santos; Beatriz Meurer Moreira; Sergio Eduardo Longo Fracalanzza; Raquel Regina Bonelli Journal: Braz J Microbiol Date: 2017-07-12 Impact factor: 2.476
Authors: Daniel O Connor; Lena Danckert; Sebastian Hoppe; Frank F Bier; Markus von Nickisch-Rosenegk Journal: PLoS One Date: 2017-07-19 Impact factor: 3.240