Literature DB >> 7502081

Pineal serotonin N-acetyltransferase: expression cloning and molecular analysis.

S L Coon1, P H Roseboom, R Baler, J L Weller, M A Namboodiri, E V Koonin, D C Klein.   

Abstract

Pineal serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase, or AA-NAT) generates the large circadian rhythm in melatonin, the hormone that coordinates daily and seasonal physiology in some mammals. Complementary DNA encoding ovine AA-NAT was cloned. The abundance of AA-NAT messenger RNA (mRNA) during the day was high in the ovine pineal gland and somewhat lower in retina. AA-NAT mRNA was found unexpectedly in the pituitary gland and in some brain regions. The night-to-day ratio of ovine pineal AA-NAT mRNA is less than 2. In contrast, the ratio exceeds 150 in rats. AA-NAT represents a family within a large superfamily of acetyltransferases.

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Year:  1995        PMID： 7502081     DOI： 10.1126/science.270.5242.1681

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  61 in total

1.  Evidence for implication of tryptophan hydroxylase in the regulation of melatonin synthesis in ovine pinealocytes in culture.

Authors:  Karen Privat; Christine Brisson; Anne Jouvet; Didier Chesneau; Jean-Paul Ravault; Michelle Fevre-Montange
Journal:  Cell Mol Neurobiol       Date:  2002-08       Impact factor: 5.046

2.  Enzymatic and cellular study of a serotonin N-acetyltransferase phosphopantetheine-based prodrug.

Authors:  Yousang Hwang; Surajit Ganguly; Anthony K Ho; David C Klein; Philip A Cole
Journal:  Bioorg Med Chem       Date:  2006-12-13       Impact factor: 3.641

Review 3.  Inter-kingdom signalling: communication between bacteria and their hosts.

Authors:  David T Hughes; Vanessa Sperandio
Journal:  Nat Rev Microbiol       Date:  2008-02       Impact factor: 60.633

4.  Cloning of an arylalkylamine N-acetyltransferase (aaNAT1) from Drosophila melanogaster expressed in the nervous system and the gut.

Authors:  E Hintermann; N C Grieder; R Amherd; D Brodbeck; U A Meyer
Journal:  Proc Natl Acad Sci U S A       Date:  1996-10-29       Impact factor: 11.205

5.  Developmental and diurnal dynamics of Pax4 expression in the mammalian pineal gland: nocturnal down-regulation is mediated by adrenergic-cyclic adenosine 3',5'-monophosphate signaling.

Authors:  Martin F Rath; Michael J Bailey; Jong-So Kim; Anthony K Ho; Pascaline Gaildrat; Steven L Coon; Morten Møller; David C Klein
Journal:  Endocrinology       Date:  2008-09-25       Impact factor: 4.736

6.  A pineal regulatory element (PIRE) mediates transactivation by the pineal/retina-specific transcription factor CRX.

Authors:  X Li; S Chen; Q Wang; D J Zack; S H Snyder; J Borjigin
Journal:  Proc Natl Acad Sci U S A       Date:  1998-02-17       Impact factor: 11.205

7.  Melatonin Synthesis: Acetylserotonin O-Methyltransferase (ASMT) Is Strongly Expressed in a Subpopulation of Pinealocytes in the Male Rat Pineal Gland.

Authors:  Martin F Rath; Steven L Coon; Fernanda G Amaral; Joan L Weller; Morten Møller; David C Klein
Journal:  Endocrinology       Date:  2016-03-07       Impact factor: 4.736

8.  Sulfation of 6-hydroxymelatonin, N-acetylserotonin and 4-hydroxyramelteon by the human cytosolic sulfotransferases (SULTs).

Authors:  Lijun Luo; Chunyang Zhou; Katsuhisa Kurogi; Yoichi Sakakibara; Masahito Suiko; Ming-Cheh Liu
Journal:  Xenobiotica       Date:  2015-11-17       Impact factor: 1.908

9.  Evolution of AANAT: expansion of the gene family in the cephalochordate amphioxus.

Authors:  Jiri Pavlicek; Sandrine Sauzet; Laurence Besseau; Steven L Coon; Joan L Weller; Gilles Boeuf; Pascaline Gaildrat; Marina V Omelchenko; Eugene V Koonin; Jack Falcón; David C Klein
Journal:  BMC Evol Biol       Date:  2010-05-25       Impact factor: 3.260

10.  Diurnal variation of the adenylyl cyclase type 1 in the rat pineal gland.

Authors:  E T Tzavara; Y Pouille; N Defer; J Hanoune
Journal:  Proc Natl Acad Sci U S A       Date:  1996-10-01       Impact factor: 11.205
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