Literature DB >> 7501917

[Surgery of colorectal carcinoma].

H Becker1.   

Abstract

Surgery is the primary mode of therapy for colonic and rectal cancer. The principles of surgery are: laparotomy for staging, wide en bloc resection of the primary tumor and lymphadenectomy for staging as well as possible therapeutic benefit. Reasonable efforts should be made intraoperatively to prevent intraluminal and intraperitoneal spread. Resection of metastases can prolong survival in stage D patients confined to the liver. Dukes C colon cancer patients should receive multiagent chemotherapy. There is no well defined role for radiation therapy as adjuvant treatment in colon cancer. Local failure pattern and treatment strategies are different for cancer of the rectum. Surgery remains the mainstay of treatment for all lesions; other modalities are adjunctive. Lesions within 5 cm of the anal verge usually require abdominoperineal resection, while the other are treated with a low anterior resection. New techniques are emerging to preserve the anal sphincter and gastrointestinal continuity, and these are being tested to determine if adequate tumor control is obtained.

Entities:  

Mesh:

Year:  1995        PMID: 7501917

Source DB:  PubMed          Journal:  Praxis (Bern 1994)        ISSN: 1661-8157


  5 in total

1.  Computational analysis of mRNA expression profiles identifies microRNA-29a/c as predictor of colorectal cancer early recurrence.

Authors:  Tai-Yue Kuo; Edward Hsi; I-Ping Yang; Pei-Chien Tsai; Jaw-Yuan Wang; Suh-Hang Hank Juo
Journal:  PLoS One       Date:  2012-02-13       Impact factor: 3.240

2.  Aberrant expression of LncRNA CASC2 mediated the cell viability, apoptosis and autophagy of colon cancer cells by sponging miR-19a via NF-κB signaling pathway.

Authors:  Peng Zhang; Yan Pan; Jujun Sun; Gaiyan Pan
Journal:  Int J Exp Pathol       Date:  2021-05-13       Impact factor: 2.793

3.  The functional significance of microRNA-29c in patients with colorectal cancer: a potential circulating biomarker for predicting early relapse.

Authors:  I-Ping Yang; Hsiang-Lin Tsai; Ching-Wen Huang; Ming-Yii Huang; Ming-Feng Hou; Suh-Hang Hank Juo; Jaw-Yuan Wang
Journal:  PLoS One       Date:  2013-06-28       Impact factor: 3.240

4.  High blood sugar levels significantly impact the prognosis of colorectal cancer patients through down-regulation of microRNA-16 by targeting Myb and VEGFR2.

Authors:  I-Ping Yang; Hsiang-Lin Tsai; Ching-Wen Huang; Chien-Yu Lu; Zhi-Feng Miao; Se-Fen Chang; Suh-Hang Hank Juo; Jaw-Yuan Wang
Journal:  Oncotarget       Date:  2016-04-05

5.  A robust gene signature for the prediction of early relapse in stage I-III colon cancer.

Authors:  Weixing Dai; Yaqi Li; Shaobo Mo; Yang Feng; Long Zhang; Ye Xu; Qingguo Li; Guoxiang Cai
Journal:  Mol Oncol       Date:  2018-02-16       Impact factor: 6.603

  5 in total

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