Literature DB >> 7500753

Is Kaposi's-sarcoma-associated herpesvirus detectable in semen of HIV-infected homosexual men?

J C Lin1, S C Lin, E C Mar, P E Pellett, F R Stamey, J A Stewart, T J Spira.   

Abstract

We explored a possible route of transmission of Kaposi's-sarcoma-associated herpes virus (KSHV) with nested and unnested PCR techniques. We looked for KSHV DNA sequences in semen of HIV-positive homosexual men and HIV-negative healthy semen donors. With unnested primers we found KSHV sequences in 21 of 33 (64%) homosexual men and in none of 30 healthy donors. With a nested PCR assay, 30 of 33 (91%) specimens from the homosexual men and 7 of 30 (23%) specimens from healthy donors had detectable KSHV sequences. Over 5 years of follow-up, 13 of 30 KSHV-positive homosexual men (43%) developed KS compared with none of the 3 KSHV-negative homosexual men.

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Year:  1995        PMID： 7500753     DOI： 10.1016/s0140-6736(95)91931-7

Source DB:  PubMed          Journal:  Lancet        ISSN： 0140-6736            Impact factor:   79.321


  15 in total

1.  Multicenter comparison of PCR assays for detection of human herpesvirus 8 DNA in semen.

Authors:  P E Pellett; T J Spira; O Bagasra; C Boshoff; L Corey; L de Lellis; M L Huang; J C Lin; S Matthews; P Monini; P Rimessi; C Sosa; C Wood; J A Stewart
Journal:  J Clin Microbiol       Date:  1999-05       Impact factor: 5.948

Review 2.  Kaposi's sarcoma associated herpes virus (KSHV/HHV 8): epidemiology, molecular biology and tissue distribution.

Authors:  J J O'Leary; M M Kennedy; J O McGee
Journal:  Mol Pathol       Date:  1997-02

Review 3.  Cell-homologous genes in the Kaposi's sarcoma-associated rhadinovirus human herpesvirus 8: determinants of its pathogenicity?

Authors:  F Neipel; J C Albrecht; B Fleckenstein
Journal:  J Virol       Date:  1997-06       Impact factor: 5.103

4.  HHV8 and Kaposi's sarcoma: a time cohort study.

Authors:  M M Kennedy; S B Lucas; R R Jones; D D Howells; S J Picton; E E Hanks; J O McGee; J J O'Leary
Journal:  Mol Pathol       Date:  1997-04

5.  Identification, expression, and immunogenicity of Kaposi's sarcoma-associated herpesvirus-encoded small viral capsid antigen.

Authors:  S F Lin; R Sun; L Heston; L Gradoville; D Shedd; K Haglund; M Rigsby; G Miller
Journal:  J Virol       Date:  1997-04       Impact factor: 5.103

6.  Analysis of the pathogenetic basis for shedding and transmission of ovine gamma herpesvirus 2.

Authors:  Daniela Hüssy; Fredi Janett; Sarah Albini; Norbert Stäuber; Rico Thun; Mathias Ackermann
Journal:  J Clin Microbiol       Date:  2002-12       Impact factor: 5.948

7.  Human herpesvirus 8 seroprevalence and evaluation of nonsexual transmission routes by detection of DNA in clinical specimens from human immunodeficiency virus-seronegative patients from central and southern Italy, with and without Kaposi's sarcoma.

Authors:  P Cattani; M Capuano; F Cerimele; I L La Parola; R Santangelo; C Masini; D Cerimele; G Fadda
Journal:  J Clin Microbiol       Date:  1999-04       Impact factor: 5.948

8.  Detection of the herpesvirus-like DNA sequences in matched specimens of semen and blood from patients with AIDS-related Kaposi's sarcoma by polymerase chain reaction in situ hybridization.

Authors:  Y Q Huang; J J Li; B J Poiesz; M H Kaplan; A E Friedman-Kien
Journal:  Am J Pathol       Date:  1997-01       Impact factor: 4.307

Review 9.  Spectrum of Kaposi's sarcoma-associated herpesvirus, or human herpesvirus 8, diseases.

Authors:  Dharam V Ablashi; Louise G Chatlynne; James E Whitman; Ethel Cesarman
Journal:  Clin Microbiol Rev       Date:  2002-07       Impact factor: 26.132

10.  A seroprevalence study of human herpesvirus type 8 (HHV8) in eastern and Central Africa and in the Mediterranean area.

Authors:  D Serraino; L Toma; M Andreoni; S Buttò; O Tchangmena; L Sarmati; P Monini; S Franceschi; B Ensoli; G Rezza
Journal:  Eur J Epidemiol       Date:  2001       Impact factor: 8.082
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