Z N Mo1, X Huang, S C Zhang, J R Yang. 1. Urology Department, Second Affiliated Hospital of Hunan Medical University, Peoples Republic of China.
Abstract
PURPOSE: We investigated whether the association between vasectomy and prostate cancer has a hormonal basis. MATERIALS AND METHODS: We examined serum testosterone, dihydrotestosterone, luteinizing hormone and follicle-stimulating hormone levels by radioimmunoassay on 91 pairs of men who did and did not undergo vasectomy. RESULTS: Men who underwent vasectomy 10 to 19 years previously had higher dihydrotestosterone levels than age matched controls. In men who underwent vasectomy 20 years or more ago testosterone was higher than in corresponding controls. No statistically significant difference in luteinizing hormone and follicle-stimulating hormone levels was noted between the men who had had vasectomy and controls. CONCLUSIONS: Our results indirectly support the hypothesis that there is an elevated risk of prostate cancer among men who underwent vasectomy 20 or more years previously.
PURPOSE: We investigated whether the association between vasectomy and prostate cancer has a hormonal basis. MATERIALS AND METHODS: We examined serum testosterone, dihydrotestosterone, luteinizing hormone and follicle-stimulating hormone levels by radioimmunoassay on 91 pairs of men who did and did not undergo vasectomy. RESULTS:Men who underwent vasectomy 10 to 19 years previously had higher dihydrotestosterone levels than age matched controls. In men who underwent vasectomy 20 years or more ago testosterone was higher than in corresponding controls. No statistically significant difference in luteinizing hormone and follicle-stimulating hormone levels was noted between the men who had had vasectomy and controls. CONCLUSIONS: Our results indirectly support the hypothesis that there is an elevated risk of prostate cancer among men who underwent vasectomy 20 or more years previously.
Entities:
Keywords:
Age Factors--men; Androgens; Asia; Biology; Cancer--men; Case Control Studies; China; Demographic Factors; Developing Countries; Diseases; Eastern Asia; Endocrine System; Family Planning; Follicle Stimulating Hormone; Genitalia; Genitalia, Male; Gonadotropins; Gonadotropins, Pituitary; Hormones; Luteinizing Hormone; Male Sterilization; Neoplasms; Physiology; Population; Population Characteristics; Population Dynamics; Prostate; Research Methodology; Research Report; Retrospective Studies; Sterilization, Sexual; Studies; Testis; Testosterone; Time Factors; Urogenital System; Vasectomy--side effects
Authors: Bimal Bhindi; Christopher J D Wallis; Madhur Nayan; Ann M Farrell; Landon W Trost; Robert J Hamilton; Girish S Kulkarni; Antonio Finelli; Neil E Fleshner; Stephen A Boorjian; R Jeffrey Karnes Journal: JAMA Intern Med Date: 2017-09-01 Impact factor: 21.873
Authors: Mohummad Minhaj Siddiqui; Kathryn M Wilson; Mara M Epstein; Jennifer R Rider; Neil E Martin; Meir J Stampfer; Edward L Giovannucci; Lorelei A Mucci Journal: J Clin Oncol Date: 2014-09-20 Impact factor: 44.544
Authors: Karl Smith; Jose Maria Castaño; Maria Dolores Chirlaque; Hans Lilja; Antonio Agudo; Eva Ardanaz; Miguel Rodríguez-Barranco; Heiner Boeing; Rudolf Kaaks; Kay-Tee Khaw; Nerea Larrañaga; Carmen Navarro; Anja Olsen; Kim Overvad; Aurora Perez-Cornago; Sabine Rohrmann; Maria José Sánchez; Anne Tjønneland; Konstantinos K Tsilidis; Mattias Johansson; Elio Riboli; Timothy J Key; Ruth C Travis Journal: J Clin Oncol Date: 2017-03-06 Impact factor: 44.544
Authors: Madhur Nayan; Robert J Hamilton; Erin M Macdonald; Qing Li; Muhammad M Mamdani; Craig C Earle; Girish S Kulkarni; Keith A Jarvi; David N Juurlink Journal: BMJ Date: 2016-11-03