Literature DB >> 7499364

Molecular cloning of a novel laminin chain, alpha 5, and widespread expression in adult mouse tissues.

J H Miner1, R M Lewis, J R Sanes.   

Abstract

We have identified a fifth member of the alpha subfamily of vertebrate laminin chains. Sequence analysis revealed a close relationship of alpha 5 to the only known Drosophila alpha chain, suggesting that the ancestral alpha gene was more similar to alpha 5 than to alpha 1-4. Analysis of RNA expression showed that alpha 5 is widely expressed in adult tissues, with highest levels in lung, heart, and kidney. Our results suggest that alpha 5 may be a major laminin chain of adult basal laminae.

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Year:  1995        PMID： 7499364     DOI： 10.1074/jbc.270.48.28523

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  48 in total

1.  Complete sequence, recombinant analysis and binding to laminins and sulphated ligands of the N-terminal domains of laminin alpha3B and alpha5 chains.

Authors:  Jörg H O Garbe; Walter Göhring; Karlheinz Mann; Rupert Timpl; Takako Sasaki
Journal:  Biochem J       Date:  2002-02-15       Impact factor: 3.857

2.  Laminin expression in adult and developing retinae: evidence of two novel CNS laminins.

Authors:  R T Libby; M F Champliaud; T Claudepierre; Y Xu; E P Gibbons; M Koch; R E Burgeson; D D Hunter; W J Brunken
Journal:  J Neurosci       Date:  2000-09-01       Impact factor: 6.167

3.  Extrasynaptic location of laminin beta 2 chain in developing and adult human skeletal muscle.

Authors:  U M Wewer; L E Thornell; F Loechel; X Zhang; M E Durkin; S Amano; R E Burgeson; E Engvall; R Albrechtsen; I Virtanen
Journal:  Am J Pathol       Date:  1997-08       Impact factor: 4.307

4.  Laminin-10 is crucial for hair morphogenesis.

Authors:  Jie Li; Julia Tzu; Yi Chen; Yan-Ping Zhang; Ngon T Nguyen; Jing Gao; Maria Bradley; Douglas R Keene; Anthony E Oro; Jeffrey H Miner; M Peter Marinkovich
Journal:  EMBO J       Date:  2003-05-15       Impact factor: 11.598

Review 5.  Dynamic (re)organization of the podocyte actin cytoskeleton in the nephrotic syndrome.

Authors:  Jun Oh; Jochen Reiser; Peter Mundel
Journal:  Pediatr Nephrol       Date:  2003-12-13       Impact factor: 3.714

Review 6.  Lung organogenesis.

Authors:  David Warburton; Ahmed El-Hashash; Gianni Carraro; Caterina Tiozzo; Frederic Sala; Orquidea Rogers; Stijn De Langhe; Paul J Kemp; Daniela Riccardi; John Torday; Saverio Bellusci; Wei Shi; Sharon R Lubkin; Edwin Jesudason
Journal:  Curr Top Dev Biol       Date:  2010       Impact factor: 4.897

7.  Overexpression of laminin-8 in human dermal microvascular endothelial cells promotes angiogenesis-related functions.

Authors:  Jie Li; Lisa Zhou; Hoang T Tran; Yi Chen; Ngon E Nguyen; Marvin A Karasek; M Peter Marinkovich
Journal:  J Invest Dermatol       Date:  2006-02       Impact factor: 8.551

8.  Substitution of a conserved cysteine-996 in a cysteine-rich motif of the laminin alpha2-chain in congenital muscular dystrophy with partial deficiency of the protein.

Authors:  M Nissinen; A Helbling-Leclerc; X Zhang; T Evangelista; H Topaloglu; C Cruaud; J Weissenbach; M Fardeau; F M Tomé; K Schwartz; K Tryggvason; P Guicheney
Journal:  Am J Hum Genet       Date:  1996-06       Impact factor: 11.025

9.  A hypomorphic mutation in the mouse laminin alpha5 gene causes polycystic kidney disease.

Authors:  M Brendan Shannon; Bruce L Patton; Scott J Harvey; Jeffrey H Miner
Journal:  J Am Soc Nephrol       Date:  2006-06-21       Impact factor: 10.121

10.  The synaptic CT carbohydrate modulates binding and expression of extracellular matrix proteins in skeletal muscle: Partial dependence on utrophin.

Authors:  Jung Hae Yoon; Kumaran Chandrasekharan; Rui Xu; Matthew Glass; Neha Singhal; Paul T Martin
Journal:  Mol Cell Neurosci       Date:  2009-05-12       Impact factor: 4.314
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