Literature DB >> 7498543

Formation of 8-nitroguanine in DNA treated with peroxynitrite in vitro and its rapid removal from DNA by depurination.

V Yermilov1, J Rubio, H Ohshima.   

Abstract

Peroxynitrite is a strong oxidant formed by reaction of nitric oxide with superoxide in inflamed tissues. We have demonstrated that 8-nitroguanine is formed dose-dependently in calf thymus DNA incubated with low concentrations of peroxynitrite in vitro. 8-Nitroguanine in acid-hydrolyzed DNA was chemically reduced into 8-aminoguanine, which was analyzed using high performance liquid chromatography with electrochemical detection. Only peroxynitrite, but not nitrite, tetranitromethane nor NO-releasing compounds, formed 8-nitroguanine. Antioxidants and desferrioxamine inhibited the reaction. 8-Nitroguanine was depurinated from DNA incubated at pH 7.4, 37 degrees C (t1/2 = approximately 4 h). Peroxynitrite did not increase 8-oxoguanine levels in DNA.

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Year:  1995        PMID： 7498543     DOI： 10.1016/0014-5793(95)01281-6

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  47 in total

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4.  DNA damage by peroxynitrite characterized with DNA repair enzymes.

Authors:  B Epe; D Ballmaier; I Roussyn; K Briviba; H Sies
Journal:  Nucleic Acids Res       Date:  1996-11-01       Impact factor: 16.971

5.  Nitrative and oxidative DNA damage as potential survival biomarkers for nasopharyngeal carcinoma.

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Review 8.  Oxidative stress, DNA damage, and the telomeric complex as therapeutic targets in acute neurodegeneration.

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Review 10.  Free radicals: properties, sources, targets, and their implication in various diseases.

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Journal:  Indian J Clin Biochem       Date:  2014-07-15
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