Literature DB >> 7498409

Decrease of neurotrophin-3 mRNA in adult rat hippocampus after pilocarpine seizures.

R Schmidt-Kastner1, L Olson.   

Abstract

Neurotrophins such as NT-3 are subject to complex regulation during epileptic seizures. Pilocarpine at a dose of 250 mg/kg induced either limbic seizures (LS) or limbic motor status epilepticus (LMSE) in adult rats. In situ hybridization signals for NT-3 mRNA declined moderately after LS and were nearly lost in LMSE at 3-4 h. Loss of NT-3 mRNA expression does not correlate with cell death and may reflect a functional down-regulation in certain hippocampal neurons.

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Year:  1995        PMID： 7498409     DOI： 10.1006/exnr.1995.1096

Source DB:  PubMed          Journal:  Exp Neurol        ISSN： 0014-4886            Impact factor:   5.330


  6 in total

1.  Neurotrophin-3 mRNA a putative target of miR21 following status epilepticus.

Authors:  Rashmi M Risbud; Carolyn Lee; Brenda E Porter
Journal:  Brain Res       Date:  2011-09-24       Impact factor: 3.252

2.  Immunohistochemical evidence of seizure-induced activation of trk receptors in the mossy fiber pathway of adult rat hippocampus.

Authors:  D K Binder; M J Routbort; J O McNamara
Journal:  J Neurosci       Date:  1999-06-01       Impact factor: 6.167

Review 3.  Epilepsy as an example of neural plasticity.

Authors:  Helen E Scharfman
Journal:  Neuroscientist       Date:  2002-04       Impact factor: 7.519

4.  Serum Levels of Growth-Associated Protein-43 and Neurotrophin-3 in Childhood Epilepsy and Their Relation to Zinc Levels.

Authors:  Ali Helmi Bakri; Mohammed H Hassan; Ahmed El-Abd Ahmed; Ghallab Alotaibi; Pola Rafat Halim; Ahmed Alamir Mahmoud Abdallah; Nagwan I Rashwan
Journal:  Biol Trace Elem Res       Date:  2022-03-29       Impact factor: 3.738

5.  Selective inhibition of kindling development by intraventricular administration of TrkB receptor body.

Authors:  D K Binder; M J Routbort; T E Ryan; G D Yancopoulos; J O McNamara
Journal:  J Neurosci       Date:  1999-02-15       Impact factor: 6.167

6.  The microRNA miR-21 conditions the brain to protect against ischemic and traumatic injuries.

Authors:  Mary S Lopez; Robert J Dempsey; Raghu Vemuganti
Journal:  Cond Med       Date:  2017-12-15
  6 in total

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