| Literature DB >> 7498295 |
V W Pike1, J A McCarron, A A Lammerstma, S P Hume, K Poole, P M Grasby, A Malizia, I A Cliffe, A Fletcher, C J Bench.
Abstract
The selective 5-HT1A receptor radioligand, [11C]WAY-100635 ([11C]N-2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-2- pyridyl)cyclohexanecarboxamide), has been injected intravenously into healthy male volunteers and studied by PET (positron emission tomography). The results provide the first delineation of 5-HT1A receptors in living human brain and demonstrate the potential to use [11C]WAY-100635 for the study of central 5-HT1A receptors in patients with psychiatric and neurological disorders and for the investigation of the pharmacology of drugs acting on the central nervous system.Entities:
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Year: 1995 PMID： 7498295 DOI： 10.1016/0014-2999(95)00438-q
Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432