| Literature DB >> 7496371 |
C F Foulon1, Y Z Zhang, S J Adelstein, A I Kassis.
Abstract
The fastest and most reliable preparation of radiolabeled 5-iodo-2'-deoxyuridine ([123/125/131I]IUdR) is accomplished by iododemetallation. We describe a series of improvements to a previously published synthesis of radiolabeled IUdR by demercuration whereby [123/125/131I]IUdR is synthesized instantly following the incubation of an aqueous solution of the chloromercury precursor with Na123/125/131I in the presence of Iodogen. The total procedure is completed in 5 min and does not require purification. Mercury content is low and HPLC indicates the total transformation of iodide into IUdR with no detectable UV-absorbing by-products.Entities:
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Year: 1995 PMID： 7496371 DOI： 10.1016/0969-8043(95)00214-x
Source DB: PubMed Journal: Appl Radiat Isot ISSN： 0969-8043 Impact factor: 1.513