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Literature DB >> 7496135

Transferrin microheterogeneity as a probe in normal and disease states.

G De Jong¹, R Feelders, W L Van Noort, H G Van Eijk.

Abstract

Isoelectric focusing of iron saturated serum has been established as a convenient method for showing transferrin glycan microheterogeneity. In a clinical setting, the method is used in the detection of cerebrospinal fluid leakage, the screening for surreptitious alcohol abuse and in the diagnosis of the carbohydrate deficient glycoprotein syndrome. In normal physiological states it can also be used as a tool to probe for changes in N-glycosylation.

Entities: Chemical Disease Gene

Mesh：

Substances：

Year: 1995 PMID： 7496135 DOI： 10.1007/bf00731323

Source DB: PubMed Journal: Glycoconj J ISSN： 0282-0080 Impact factor: 2.916

19 in total

Review 1. The biology of transferrin.

Authors: G de Jong; J P van Dijk; H G van Eijk
Journal: Clin Chim Acta Date: 1990-09 Impact factor: 3.786

2. Disialotransferrin developmental deficiency syndrome.

Authors: B Kristiansson; M Andersson; B Tonnby; B Hagberg
Journal: Arch Dis Child Date: 1989-01 Impact factor: 3.791

3. Microheterogeneity of human serum transferrin: a biological phenomenon studied by isoelectric focusing in immobilized pH gradients.

Authors: G de Jong; H G van Eijk
Journal: Electrophoresis Date: 1988-09 Impact factor: 3.535

Review 4. Structure, biosynthesis and functions of glycoprotein glycans.

Authors: E G Berger; E Buddecke; J P Kamerling; A Kobata; J C Paulson; J F Vliegenthart
Journal: Experientia Date: 1982-10-15

Review 5. The phenomenon of the acute phase response.

Authors: I Kushner
Journal: Ann N Y Acad Sci Date: 1982 Impact factor: 5.691

6. The structural heterogeneity of the carbohydrate moiety of desialylated human transferrin.

Authors: L März; M W Hatton; L R Berry; E Regoeczi
Journal: Can J Biochem Date: 1982-06

7. Solution conformation of the biantennary N-linked oligosaccharide of human serotransferrin using 1H NMR nuclear Overhauser effect measurements.

Authors: S W Homans; R A Dwek; D L Fernandes; T W Rademacher
Journal: FEBS Lett Date: 1982-12-27 Impact factor: 4.124

Transferrin microheterogeneity as a probe in normal and disease states.

Review 1. The biology of transferrin.

2. Disialotransferrin developmental deficiency syndrome.

3. Microheterogeneity of human serum transferrin: a biological phenomenon studied by isoelectric focusing in immobilized pH gradients.

Review 4. Structure, biosynthesis and functions of glycoprotein glycans.

Review 5. The phenomenon of the acute phase response.

6. The structural heterogeneity of the carbohydrate moiety of desialylated human transferrin.

7. Solution conformation of the biantennary N-linked oligosaccharide of human serotransferrin using 1H NMR nuclear Overhauser effect measurements.

Review 8. Review of isoelectric focusing for Gc, PGM1, Tf, and Pi subtypes: population distributions.

9. Human transferrin polymorphism.

10. Adaptation of transferrin protein and glycan synthesis.

1. Changes in concanavalin A-reactive proteins in neurological disorders.